Takahashi Tsutomu, Sasabayashi Daiki, Velakoulis Dennis, Suzuki Michio, McGorry Patrick D, Pantelis Christos, Chanen Andrew M
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.
Front Psychiatry. 2022 Nov 3;13:1033918. doi: 10.3389/fpsyt.2022.1033918. eCollection 2022.
Inter-individual variations in the sulco-gyral pattern of Heschl's gyrus (HG) might contribute to emotional processing. However, it remains largely unknown whether borderline personality disorder (BPD) patients exhibit an altered HG gyrification pattern, compared with healthy individuals, and whether such a brain morphological feature, if present, might contribute to their clinical characteristics. The present study used magnetic resonance imaging to investigate the distribution of HG gyrification patterns (single or duplicated) and their relationship to clinical characteristics in teenage BPD patients with minimal treatment exposure. No significant difference was noted for the prevalence of HG patterns between 20 BPD and 20 healthy participants. However, the BPD participants with left duplicated HG were characterized by higher prevalence of comorbid disruptive behavior disorders, with higher externalizing score compared with those with left single HG. Our preliminary results suggest that neurodevelopmental pathology associated with gyral formation might be implicated in the neurobiology of early BPD, especially for emotional and behavioral control.
颞横回（HG）脑沟回模式的个体间差异可能有助于情绪加工。然而，与健康个体相比，边缘型人格障碍（BPD）患者的HG脑回形成模式是否改变，以及这种脑形态特征（如果存在）是否可能导致其临床特征，在很大程度上仍不清楚。本研究使用磁共振成像来研究HG脑回形成模式（单回或双回）的分布及其与极少接受治疗的青少年BPD患者临床特征的关系。在20名BPD患者和20名健康参与者之间，HG模式的患病率没有显著差异。然而，左侧HG双回的BPD参与者共病破坏性行为障碍的患病率较高，与左侧HG单回的参与者相比，其外化得分更高。我们的初步结果表明，与脑回形成相关的神经发育病理学可能与早期BPD的神经生物学有关，特别是在情绪和行为控制方面。
