Lee E H, Lin Y P, Yin T H
Institute of Biomedial Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
Physiol Behav. 1988;42(1):97-102. doi: 10.1016/0031-9384(88)90267-3.
Roles of the lateral and medial septum in the regulation of activity, reactivity and open field behavior in rats were examined in the present study. Effects of lateral, medial and combined lateral and medial septal lesions were studied, respectively. Our results indicate that lateral septal lesions significantly decreased locomotor activity and tended to decrease rearing response. While it also markedly increased movement time in the activity monitor, stereotyped behavior and tactile startle amplitude. The most significant findings with medial septal lesions were decreased activity, especially in the center area of an open field and decreased exploratory behavior in rats. For most behavioral measures, effects of combined lateral and medial septal lesions were similar to that of medial septal lesions alone except that it augmented startle response with a different response pattern compared to that of lateral septal lesions alone. The locomotion patterns of these animals also revealed some qualitative difference in their behavior. These results are further discussed in the scope of anatomical, neurochemical and pharmacological differentiations of the septum complex.
本研究考察了大鼠外侧隔区和内侧隔区在调节活动、反应性及旷场行为中的作用。分别研究了外侧隔区、内侧隔区以及外侧和内侧隔区联合损伤的影响。我们的结果表明，外侧隔区损伤显著降低了运动活性，并倾向于减少竖毛反应。同时，它还显著增加了活动监测器中的运动时间、刻板行为和触觉惊跳幅度。内侧隔区损伤最显著的结果是活动减少，尤其是在旷场中央区域，以及大鼠探索行为减少。对于大多数行为指标，外侧和内侧隔区联合损伤的影响与单独内侧隔区损伤相似，只是与单独外侧隔区损伤相比，它增强了惊跳反应，且反应模式不同。这些动物的运动模式也揭示了它们行为上的一些质的差异。在隔区复合体的解剖学、神经化学和药理学差异范围内，对这些结果进行了进一步讨论。
