School of Dentistry, The University of Queensland, Brisbane, Queensland 4006, Australia.
Curr Aging Sci. 2021;14(3):181-190. doi: 10.2174/1874609814666210419104547.
Currently, the focus of anti-aging research has been changed from geriatrics to biogerontology. This has taken anti-aging strategies from cost-effective but palliative therapeutics to active, molecular approaches.
Over the years, a large body of basic gerontological research has indicated that the process of biological aging is closely associated with genetic factors. This leads to the development of various gene therapies such as RNA interference technology and results in a subsequent need for translating laboratory achievements into clinical applications. The translation has been a tremendous challenge at this stage with respect to the practicality, safety, and effectiveness of the genetic manipulation techniques.
This review summarizes the current development of anti-aging strategies and the progress in the translation of laboratory achievements into clinical applications, highlights challenges encountered, and provides a prospective outlook for future anti-aging research.
目前，抗衰老研究的重点已经从老年医学转向生物老年学。这使得抗衰老策略从经济有效的姑息治疗转变为积极的、分子水平的方法。
多年来，大量的基础老年学研究表明，生物衰老过程与遗传因素密切相关。这导致了各种基因治疗方法的发展，如 RNA 干扰技术，并导致随后需要将实验室成果转化为临床应用。在现阶段，从遗传操作技术的实用性、安全性和有效性来看，转化面临着巨大的挑战。
本文综述了抗衰老策略的最新进展以及将实验室成果转化为临床应用的进展，强调了所遇到的挑战，并对未来的抗衰老研究进行了前瞻性展望。
