ÉCOBES - Recherche et transfert, Cégep de Jonquière, Jonquière, Québec, Canada.
Département des sciences de la santé, Université du Québec à Chicoutimi, Chicoutimi, Québec, Canada.
Can J Neurol Sci. 2022 Mar;49(2):287-290. doi: 10.1017/cjn.2021.77. Epub 2021 Apr 20.
Daytime sleepiness and fatigue are prominent symptoms of myotonic dystrophy type 1 (DM1) that can be amenable to treatment in the context of randomized controlled trials. No study has yet documented whether self-reported measures of daytime sleepiness and fatigue can detect change over time and the meaning of this change. The aim was to explore indicators of responsiveness to change and interpretability for the Daytime Sleepiness Scale and the Fatigue Severity Scale in 115 DM1 prospectively followed patients. Results suggest that these two self-reported questionnaires are sufficiently sensitive to detect changes beyond expected measurement error over time in this population.
白天嗜睡和疲劳是 1 型肌强直性营养不良（DM1）的突出症状，在随机对照试验的背景下可以进行治疗。目前尚无研究记录自我报告的白天嗜睡和疲劳测量是否能够随时间检测到变化以及这种变化的意义。本研究旨在探讨日间嗜睡量表和疲劳严重程度量表在 115 例前瞻性随访的 DM1 患者中的反应变化指标和可解释性。结果表明，这两个自我报告问卷在该人群中足够敏感，能够检测到随时间推移超过预期测量误差的变化。
