Gallais Benjamin, Gagnon Cynthia, Forgues Geneviève, Côté Isabelle, Laberge Luc
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-St-Jean, Hôpital de Jonquière, Saguenay, Québec, Canada; Centre de recherche Charles-Le-Moyne, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-St-Jean, Hôpital de Jonquière, Saguenay, Québec, Canada; Département des sciences de la santé, Université du Québec à Chicoutimi, Saguenay, Québec, Canada.
J Neurol Sci. 2017 Apr 15;375:23-26. doi: 10.1016/j.jns.2017.01.032. Epub 2017 Jan 10.
Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disease causing, among other symptoms, fatigue and excessive daytime sleepiness, which are frequently undifferentiated by patients and/or clinicians. The Fatigue and Daytime Sleepiness Scale (FDSS) has been devised to measure these two overlapping symptoms as a single clinical entity.
To further examine the reliability and the construct validity of the FDSS in patients with DM1.
The scale was administered to 48 DM1 patients on two occasions at a 2week-interval. Intra-rater reliability and internal consistency were established by calculating the intraclass correlation coefficient (ICC) and Cronbach's alpha, respectively. Construct validity was assessed by using the known-group method. More precisely, the mean FDSS score of patients with and without subjective complaints of fatigue and/or sleepiness was compared.
The FDSS showed good intra-rater reliability (ICC=0.83) and acceptable internal consistency (Cronbach's alpha =0.6). Also, the FDSS was able to distinguish between patients who had fatigue and sleepiness complaints from those who did not (mean FDSS score of 10.6 vs 8.0, p=0.01), suggesting good construct validity.
Overall, the present study supports the continued use of the FDSS as a reliable and valid instrument to measure fatigue and daytime sleepiness in patients with DM1 for either clinical or research purposes.
1型强直性肌营养不良症（DM1）是一种遗传性神经肌肉疾病，除其他症状外，还会导致疲劳和日间过度嗜睡，而患者和/或临床医生常常无法区分这些症状。疲劳和日间嗜睡量表（FDSS）旨在将这两种重叠症状作为一个单一临床实体进行测量。
进一步检验FDSS在DM1患者中的可靠性和结构效度。
对48例DM1患者每隔2周进行两次量表测评。分别通过计算组内相关系数（ICC）和克朗巴哈系数（Cronbach's alpha）来确定评分者内信度和内部一致性。采用已知组法评估结构效度。更确切地说，比较了有和没有疲劳和/或嗜睡主观主诉的患者的平均FDSS评分。
FDSS显示出良好的评分者内信度（ICC = 0.
