Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
Institute of Comparative Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0271220. doi: 10.1128/AAC.02712-20.
The emergence and transmission of novel antimicrobial resistance genes pose a great threat to public health globally. Recently, the plasmid-encoding RND efflux pump TMexCD1-TOprJ1 in Klebsiella pneumoniae was reported to reduce the sensitivity of multiple antimicrobials. Here, we identified a pandrug-resistant Proteus mirabilis isolate that harbored the novel gene cluster located on SXT/R391 ICE. This study expands current knowledge of the transfer mechanisms of like gene clusters among P. mirabilis isolates and warrants further genomic epidemiology investigations.
新型抗菌药物耐药基因的出现和传播对全球公共卫生构成了巨大威胁。最近，肺炎克雷伯菌中携带的质粒编码的 RND 外排泵 TMexCD1-TOprJ1 被报道降低了多种抗菌药物的敏感性。在这里，我们鉴定了一株泛耐药奇异变形杆菌分离株，该分离株携带位于 SXT/R391 ICE 上的新型基因簇。本研究扩展了目前对奇异变形杆菌分离株中类似基因簇转移机制的认识，值得进一步进行基因组流行病学研究。
