Zhu Yinan, Cresswell Manuela, Charnock Jonathan Miles, Reece Philip
ENT, University Hospitals Plymouth NHS Trust, Plymouth, UK
ENT, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
BMJ Case Rep. 2021 Apr 19;14(4):e240980. doi: 10.1136/bcr-2020-240980.
This case series reports familial cases of nodular oncocytic hyperplasia (NOH) diagnosed in a mother and her son, 15 years apart. A 39-year-old man presented in 2003 with a lump below his left ear. Magnetic resonance imaging (MRI) performed showed multifocal parotid nodules and a diagnosis of NOH was histopathologically confirmed following left total parotidectomy. Two years later, he represented with similar symptoms on the right side. NOH was diagnosed following excision of his right parotid gland. In 2018, his 73-year-old mother presented with left ear pain and a lump below her left ear. An MRI scan showed multiple lesions within both parotid glands and bilateral NOH was once again diagnosed following a left superficial parotidectomy and right total parotidectomy. We believe that this is the first reported case of bilateral familial NOH.
本病例系列报告了一例结节性嗜酸性细胞增生症(NOH)的家族病例,患者为一位母亲及其儿子,两人发病间隔15年。2003年,一名39岁男性因左耳下方出现肿块前来就诊。磁共振成像(MRI)检查显示腮腺多发结节,左腮腺全切术后经组织病理学确诊为NOH。两年后,他右侧出现类似症状。右腮腺切除术后诊断为NOH。2018年,他73岁的母亲出现左耳疼痛及左耳下方肿块。MRI扫描显示双侧腮腺内有多个病灶,左腮腺浅叶切除术和右腮腺全切术后再次诊断为双侧家族性NOH。我们认为这是首例双侧家族性NOH的报道病例。