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比目鱼基因组的大规模测序为其特殊身体结构的多系起源提供了见解。

Large-scale sequencing of flatfish genomes provides insights into the polyphyletic origin of their specialized body plan.

作者信息

Lü Zhenming, Gong Li, Ren Yandong, Chen Yongjiu, Wang Zhongkai, Liu Liqin, Li Haorong, Chen Xianqing, Li Zhenzhu, Luo Hairong, Jiang Hui, Zeng Yan, Wang Yifan, Wang Kun, Zhang Chen, Jiang Haifeng, Wan Wenting, Qin Yanli, Zhang Jianshe, Zhu Liang, Shi Wei, He Shunping, Mao Bingyu, Wang Wen, Kong Xiaoyu, Li Yongxin

机构信息

National Engineering Laboratory of Marine Germplasm Resources Exploration and Utilization, Zhejiang Ocean University, Zhoushan, China.

School of Ecology and Environment, Northwestern Polytechnical University, Xi'an, China.

出版信息

Nat Genet. 2021 May;53(5):742-751. doi: 10.1038/s41588-021-00836-9. Epub 2021 Apr 19.

DOI:10.1038/s41588-021-00836-9
PMID:33875864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8110480/
Abstract

The evolutionary and genetic origins of the specialized body plan of flatfish are largely unclear. We analyzed the genomes of 11 flatfish species representing 9 of the 14 Pleuronectiforme families and conclude that Pleuronectoidei and Psettodoidei do not form a monophyletic group, suggesting independent origins from different percoid ancestors. Genomic and transcriptomic data indicate that genes related to WNT and retinoic acid pathways, hampered musculature and reduced lipids might have functioned in the evolution of the specialized body plan of Pleuronectoidei. Evolution of Psettodoidei involved similar but not identical genes. Our work provides valuable resources and insights for understanding the genetic origins of the unusual body plan of flatfishes.

摘要

比目鱼特殊身体结构的进化和遗传起源在很大程度上尚不清楚。我们分析了代表14个鲽形目科中9个科的11种比目鱼的基因组，得出结论：鲽亚目和鳎亚目并非单系类群，这表明它们起源于不同的鲈形目祖先。基因组和转录组数据表明，与WNT和视黄酸信号通路、受阻的肌肉组织以及减少的脂质相关的基因可能在鲽亚目特殊身体结构的进化过程中发挥了作用。鳎亚目的进化涉及相似但不完全相同的基因。我们的研究为理解比目鱼独特身体结构的遗传起源提供了宝贵的资源和见解。

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