Bernasconi A, Galleri C, Zanasi A, Zompatori M, Bazzocchi F, Fabbri M, Gavelli G
Istituto di Radiologia, Università, Bologna.
Radiol Med. 1988 Jun;75(6):589-94.
Exogenous lipid pneumonia (ELP) is caused by the aspiration of animal, vegetal or, more often, mineral oils. Even though it may also be acute, ELP is most frequently a chronic disease, affecting people with predisposing factors, such as neuromuscular disorders, structural abnormalities and so on; very often exogenous lipid pneumonia is found in tracheotomized patients. The pathology of lipid pneumonia is a chronic inflammatory process evolving in foreign-body-like reaction, and eventually in "end-stage lung" condition. Clinically, most patients are asymptomatic; few cases only present with cough, dyspnea and chest pain. Eight cases of ELP, studied over the past 3 years, are described in this paper. All the patients were examined by chest radiographs and standard tomograms; 3 patients underwent CT. X-ray features were mono/bilateral consolidation of the lower zones, with air bronchogram and variable reduction in volume. CT density was not specific for fat tissue. In all cases the diagnosis was confirmed at biopsy. In 5 patients, followed for at least one year, clinical-radiological features showed no change. Thus, complications of ELP (especially malignant evolution) could be excluded. The authors conclude that lipid pneumonia must be considered in differential diagnosis of patients with history of usage of oils and compatible X-ray findings. The usefulness of an accurate follow-up is stressed.
外源性脂质性肺炎(ELP)是由吸入动物油、植物油,或更常见的矿物油引起的。尽管它也可能是急性的,但ELP最常见的是一种慢性疾病,影响有易感因素的人群,如神经肌肉疾病、结构异常等;外源性脂质性肺炎常出现在气管切开的患者中。脂质性肺炎的病理是一个慢性炎症过程,发展为类似异物的反应,最终发展为“终末期肺”状态。临床上,大多数患者无症状;少数病例仅表现为咳嗽、呼吸困难和胸痛。本文描述了过去3年研究的8例ELP病例。所有患者均接受了胸部X光片和标准断层扫描检查;3例患者接受了CT检查。X线特征为下肺野单/双侧实变,伴有空气支气管征和不同程度的肺容积缩小。CT密度对脂肪组织不具有特异性。所有病例均经活检确诊。5例患者随访至少一年,临床放射学特征无变化。因此,可以排除ELP的并发症(尤其是恶性进展)。作者得出结论,对于有使用油类史且X线表现相符的患者,鉴别诊断时必须考虑脂质性肺炎。强调了准确随访的重要性。