在活细胞膜上对 DNA 级联电路进行编程，以实现对癌细胞的准确识别和基因沉默。
Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing.
机构信息
State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
出版信息
Chem Commun (Camb). 2021 Apr 21;57(31):3816-3819. doi: 10.1039/d1cc00481f. Epub 2021 Mar 19.
PMID:33876130
Abstract
A dual-aptamer based AND logic cascade circuit is activated on cell membranes in response to the receptor-aptamer binding, affording enhanced specificity for cell subtype recognition and gene silencing.
摘要
基于双适体的与门逻辑级联电路在细胞膜上被受体-适体结合激活，从而提高了对细胞亚型识别和基因沉默的特异性。
相似文献
1
Programming DNA cascade circuits on live cell membranes for accurate cancer cell recognition and gene silencing.
Chem Commun (Camb). 2021 Apr 21;57(31):3816-3819. doi: 10.1039/d1cc00481f. Epub 2021 Mar 19.
2
Construction of a Multiple-Aptamer-Based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification.
J Am Chem Soc. 2019 Aug 14;141(32):12738-12743. doi: 10.1021/jacs.9b05470. Epub 2019 Aug 1.
3
Engineering a Second-Order DNA Logic-Gated Nanorobot to Sense and Release on Live Cell Membranes for Multiplexed Diagnosis and Synergistic Therapy.
Angew Chem Int Ed Engl. 2021 Jul 12;60(29):15816-15820. doi: 10.1002/anie.202103993. Epub 2021 Jun 11.
4
Programming DNA-Based Biomolecular Reaction Networks on Cancer Cell Membranes.
J Am Chem Soc. 2019 Oct 23;141(42):16539-16543. doi: 10.1021/jacs.9b05598. Epub 2019 Oct 15.
5
A DNA Molecular Logic Circuit for Precise Tumor Identification.
Nano Lett. 2024 Oct 2;24(39):12070-12079. doi: 10.1021/acs.nanolett.4c02342. Epub 2024 Sep 24.
6
An aptamer-binding DNA walking machine for sensitive electrochemiluminescence detection of tumor exosomes.
Chem Commun (Camb). 2019 Dec 19;56(2):269-272. doi: 10.1039/c9cc08051a.
7
Highly Specific, Single-step Cancer Cell Isolation with Multi-Aptamer-Mediated Proximity Ligation on Live Cell Membranes.
Angew Chem Int Ed Engl. 2020 Dec 21;59(52):23564-23568. doi: 10.1002/anie.202011198. Epub 2020 Oct 15.
8
A multipedal DNA walker for amplified detection of tumor exosomes.
Chem Commun (Camb). 2020 May 7;56(37):4982-4985. doi: 10.1039/d0cc01817a. Epub 2020 Apr 14.
9
Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes.
Angew Chem Int Ed Engl. 2021 May 10;60(20):11267-11271. doi: 10.1002/anie.202102170. Epub 2021 Apr 7.
10
Detection of cancer cells using triplex DNA molecular beacons based on expression of enhanced green fluorescent protein (eGFP).
Chem Commun (Camb). 2014 Aug 28;50(67):9547-9. doi: 10.1039/c4cc03925d.
Zotero 插件