Kuffler Damien P
Institute of Neurobiology, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico 00901, USA.
Regen Med. 2021 Apr;16(4):391-404. doi: 10.2217/rme-2020-0163. Epub 2021 Apr 20.
Non-healing cutaneous wounds, including pressure, diabetic and venous ulcers, are wounds where the skin and underlying tissues die due to ischemia, infection, metabolic conditions, immunosuppression or radiation. Some can be eliminated with relatively straightforward techniques, although they may continue to grow in diameter and depth, becoming increasingly painful and never heal. Others respond more slowly or poorly to treatment, while others are recalcitrant to treatments. This review examines the etiology of non-healing wounds and different wound management treatments. In addition, it examines the efficacy of platelet-rich plasma in promoting wound healing and its potential mechanisms of action. It is concluded that platelet-rich plasma alone, but more effectively when combined with another technique(s), has the greatest potential for promoting complete wound healing. However, further studies are required to determine whether the efficacy of wound healing induced by each of these techniques is enhanced by applying the techniques simultaneously.
难愈合的皮肤伤口，包括压疮、糖尿病溃疡和静脉溃疡，是由于缺血、感染、代谢状况、免疫抑制或辐射导致皮肤及皮下组织坏死的伤口。有些伤口可以通过相对简单的技术消除，尽管它们可能会在直径和深度上继续扩大，变得越来越疼痛且永不愈合。其他伤口对治疗的反应较慢或效果不佳，还有一些伤口对治疗具有抗性。本综述探讨了难愈合伤口的病因以及不同的伤口管理治疗方法。此外，还研究了富血小板血浆在促进伤口愈合方面的功效及其潜在作用机制。得出的结论是，单独使用富血小板血浆，但与其他技术联合使用时效果更佳，在促进伤口完全愈合方面具有最大潜力。然而，需要进一步研究以确定同时应用这些技术是否能增强每种技术诱导伤口愈合的功效。
