一项全印血清流行病学调查（Phenome-India 队列）对 SARS-CoV2 的分析。
Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2.
机构信息
CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
出版信息
Elife. 2021 Apr 20;10:e66537. doi: 10.7554/eLife.66537.
To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% of which had surrogate neutralization activity. Three-fourth of these recalled no symptoms. Repeat serology tests at 3 (n = 607) and 6 (n = 175) months showed stable anti-NC antibodies but declining neutralization activity. Local seropositivity was higher in densely populated cities and was inversely correlated with a 30-day change in regional test positivity rates (TPRs). Regional seropositivity above 10% was associated with declining TPR. Personal factors associated with higher odds of seropositivity were high-exposure work (odds ratio, 95% confidence interval, p value: 2.23, 1.92-2.59, <0.0001), use of public transport (1.79, 1.43-2.24, <0.0001), not smoking (1.52, 1.16-1.99, 0.0257), non-vegetarian diet (1.67, 1.41-1.99, <0.0001), and B blood group (1.36, 1.15-1.61, 0.001).
为了了解 SARS-CoV2 的传播情况，2020 年 8 月和 9 月，印度科学与工业研究理事会（印度）在其下属的实验室和研究中心进行了血清调查。在 10427 名志愿者中，有 1058 名（10.14%）对 SARS-CoV2 核衣壳（抗-NC）抗体呈阳性，其中 95%具有替代中和活性。其中四分之三的人没有出现症状。3 个月（n=607）和 6 个月（n=175）时的重复血清学检测显示，抗-NC 抗体稳定，但中和活性下降。人口稠密城市的本地血清阳性率较高，与区域检测阳性率（TPR）的 30 天变化呈反比。区域血清阳性率超过 10%与 TPR 下降相关。与血清阳性率较高相关的个人因素包括高暴露工作（优势比，95%置信区间，p 值：2.23，1.92-2.59，<0.0001）、使用公共交通工具（1.79，1.43-2.24，<0.0001）、不吸烟（1.52，1.16-1.99，0.0257）、非素食饮食（1.67，1.41-1.99，<0.0001）和 B 型血（1.36，1.15-1.61，0.001）。
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