Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang, Hunan, 421001, China.
School of Pharmaceutical Science, Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, 421001, China.
Macromol Rapid Commun. 2021 May;42(10):e2100025. doi: 10.1002/marc.202100025. Epub 2021 Apr 20.
Injectable hydrogel possesses great application potential in disease treatment and tissue engineering, but damage to gel often occurs due to the squeezing pressure from injection devices and the mechanical forces from limb movement, and leads to the rapid degradation of gel matrix and the leakage of the load material. The self-healing injectable hydrogels can overcome these drawbacks via automatically repairing gel structural defects and restoring gel function. The polysaccharide hydrogels constructed through the Schiff base reaction own advantages including simple fabrication, injectability, and self-healing under physiological conditions, and therefore have drawn extensive attention and investigation recently. In this short review, the preparation and self-healing properties of the polysaccharide hydrogels that is established on the Schiff base reaction are focused on and their biological applications in drug delivery and cell therapy are discussed.
可注射水凝胶在疾病治疗和组织工程中具有巨大的应用潜力，但由于注射设备的挤压压力和肢体运动的机械力，凝胶往往会受到损伤，导致凝胶基质的快速降解和负载材料的泄漏。自修复可注射水凝胶可以通过自动修复凝胶结构缺陷和恢复凝胶功能来克服这些缺点。通过席夫碱反应构建的多糖水凝胶具有制备简单、可注射性以及在生理条件下的自修复性等优点，因此最近受到了广泛的关注和研究。在这篇简短的综述中，重点介绍了基于席夫碱反应的多糖水凝胶的制备和自修复特性，并讨论了其在药物传递和细胞治疗中的生物应用。
