Omkar Rheumatology Clinic, Gaikwad Mala, Nasik Road, MH 422101, India, Email:
Skin Care Clinic, Nasik, India.
J R Coll Physicians Edinb. 2021 Mar;51(1):58-60. doi: 10.4997/JRCPE.2021.114.
Systemic lupus erythematosus (SLE) is a rare autoimmune disorder in a physician's practice, commonly presenting in young females. It is rare for SLE to present at a late age. Though SLE is idiopathic, sometimes it can present as an adverse reaction to drugs. Quite a few drugs are implicated in this process. However, there are no reports of levetiracetam causing SLE. Here, we present a case of 62-year-old female presenting with SLE after consumption of levetiracetam for 1 year for her epilepsy. Erythematosus rash was her main symptom. This was associated with a strong positivity of antinuclear antibody. The symptoms remitted completely after the discontinuation of levetiracetam, suggesting them to be because of drug-induced lupus (DIL). DIL differs from SLE in being mild, affecting atypical age groups and resolving completely on withdrawal of the drug.
系统性红斑狼疮（SLE）在医生的实践中是一种罕见的自身免疫性疾病，通常在年轻女性中出现。SLE 在晚年出现的情况很少见。虽然 SLE 是特发性的，但有时它也可能是药物不良反应的表现。有很多药物与此过程有关。然而，没有报道显示左乙拉西坦会导致 SLE。在这里，我们报告了一例 62 岁女性的病例，她因癫痫服用左乙拉西坦 1 年后出现 SLE。红斑皮疹是她的主要症状。这与抗核抗体的强阳性相关。停用左乙拉西坦后，症状完全缓解，提示这是由于药物诱导的狼疮（DIL）所致。DIL 与 SLE 不同，其特点是病情较轻，影响非典型年龄组，停药后可完全缓解。
