Boostani Reza, Khodabandeh Mina, Rezaee Seyyed Abdolrahim, Rafatpanah Houshang, Ghezeldasht Sanaz Ahmadi, Vahidi Zohreh, Baghestani Zahra
Department of Neurology, Faculty of Medicine, Qaem Hospital, Mashhad University of Medical Sciences, Ahmadabad Avenue, 91766-99199, Mashhad, Iran.
Inflamation and Inflammatory Disease Research Center, School of Medicine, Mashhad University of Medical Sciences, Park Square, 9177948564, Mashhad, Iran.
J Neurovirol. 2021 Dec;27(6):831-837. doi: 10.1007/s13365-021-00961-5. Epub 2021 Apr 20.
Human T-cell lymphotropic virus type 1 (HTLV-1) infection can cause HTLV-I-associated myelopathy (HAM). In this study, we evaluated the levels of serum iron, ferritin, copper, and ceruloplasmin, and their correlations with HTLV-1 proviral load (PVL) and standard indices of HAM severity. In total, 114 subjects were recruited in this cross sectional study in Qaem Hospital, Mashhad, Iran between 2017 and 2018, including 36 HAM and 32 asymptomatic cases (ACs) and 46 healthy people (HSs). The clinical examination and evaluation of serum levels of biochemical factors and proviral load were performed. The PVL in HAM and ACs were 1835.49 ± 382.81 and 280.97 ± 67.41 copies/10 PBMCs, which statistically differed. Significant differences were also observed in plasma levels of iron, copper, and ceruloplasmin, among the three groups, while ferritin level was not considerably different. For HAM severity, the mean Osame motor disability scale (OMDS) and overactive bladder-validated-8-questionnaire (OABV-8) scores were 4.97 ± 0.38 and 15.75 ± 0.83, respectively, that had no significant correlations with the biochemical variables. Even though the studied elements in HAM group did not affect the severity of the disease, the levels of copper and ceruloplasmin might be determinants of the development and progression of HAM, as they are shown to play role in progression of other neurological diseases.
人类嗜T淋巴细胞病毒1型（HTLV-1）感染可导致HTLV-I相关脊髓病（HAM）。在本研究中，我们评估了血清铁、铁蛋白、铜和铜蓝蛋白水平，以及它们与HTLV-1前病毒载量（PVL）和HAM严重程度标准指标的相关性。2017年至2018年期间，在伊朗马什哈德的卡姆医院进行的这项横断面研究共招募了114名受试者，包括36例HAM患者、32例无症状病例（AC）和46名健康人（HS）。对生化因子血清水平和前病毒载量进行了临床检查和评估。HAM组和AC组的PVL分别为1835.49±382.81和280.97±67.41拷贝/10个外周血单核细胞，差异具有统计学意义。三组之间的铁、铜和铜蓝蛋白血浆水平也存在显著差异，而铁蛋白水平差异不显著。对于HAM严重程度，平均大见运动功能障碍量表（OMDS）和膀胱过度活动症验证8问卷（OABV-8）评分分别为4.97±0.38和15.75±0.83，与生化变量无显著相关性。尽管HAM组中所研究的元素不影响疾病的严重程度，但铜和铜蓝蛋白水平可能是HAM发生和发展的决定因素，因为它们在其他神经系统疾病的进展中发挥作用。
