Research Center for HIV/AIDS, HTLV and Viral Hepatitis, Iranian Academic Center for Education, Culture & Research (ACECR), Mashhad Branch, Mashhad, Iran.
J Clin Virol. 2011 Nov;52(3):172-6. doi: 10.1016/j.jcv.2011.07.004. Epub 2011 Aug 15.
Mashhad, in the northeast of Iran has been suggested as an endemic area for human T cell lymphotropic virus type I (HTLV-I) infection since 1996.
We performed a community-based seroepidemiology study to examine the prevalence and risk factors for HTLV-I infection in the city of Mashhad.
Between May and September 2009, overall 1678 subjects from all the 12 geographical area of Mashhad were selected randomly by multistage cluster sampling for HTLV antibody. The study population included 763 males and 915 females, with the mean age of 29.1 ± 18.5 years. 1654 serum samples were assessed for HTLV antibody using ELISA and reactive samples were confirmed by Western blot and PCR.
The overall prevalence of HTLV-I infection in whole population was 2.12% (95% CI, 1.48-2.93) with no significant difference between males and females (p = 0.093) and the prevalence of HTLV-II seropositivity was 0.12% (95% CI, 0.02-0.44). The HTLV-I Infection was associated with age (p<0.001), marital status (p<0.001), education (p = 0.047), and history of blood transfusion (p = 0.009), surgery (p<0.001), traditional cupping (p = 0.002), and hospitalization (p = 0.004). In logistic regression analysis, age was the only variable that had a significant relation with the infection (p = 0.006, OR = 4.33).
Our results demonstrated that Mashhad still remains an endemic area for HTLV-I infection despite routine blood screening. Thus, further strategies are needed for prevention of the virus transmission in whole population.
自 1996 年以来，伊朗东北部的马什哈德被认为是人类 T 细胞嗜淋巴细胞病毒 I 型（HTLV-I）感染的地方性流行区。
我们进行了一项基于社区的血清流行病学研究，以检查马什哈德市 HTLV-I 感染的流行率和危险因素。
2009 年 5 月至 9 月期间，我们通过多阶段聚类抽样选择了马什哈德 12 个地理区域的总共 1678 名受试者进行 HTLV 抗体检测。研究人群包括 763 名男性和 915 名女性，平均年龄为 29.1 ± 18.5 岁。使用 ELISA 检测了 1654 份血清样本的 HTLV 抗体，对反应性样本进行了 Western blot 和 PCR 确认。
整个人群的 HTLV-I 总感染率为 2.12%（95%CI，1.48-2.93），男性和女性之间无显著差异（p = 0.093），HTLV-II 血清阳性率为 0.12%（95%CI，0.02-0.44）。HTLV-I 感染与年龄（p<0.001）、婚姻状况（p<0.001）、教育程度（p = 0.047）和输血史（p = 0.009）、手术史（p<0.001）、传统拔罐史（p = 0.002）和住院史（p = 0.004）有关。在 logistic 回归分析中，年龄是唯一与感染有显著关系的变量（p = 0.006，OR = 4.33）。
尽管进行了常规血液筛查，但我们的结果表明马什哈德仍然是 HTLV-I 感染的地方性流行区。因此，需要针对整个人群采取进一步的策略来预防病毒传播。
