衰老相关调节细胞出现在皮下脂肪中，以抑制脂肪生成。
Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis.
机构信息
Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Department of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Endocrinology Program, University of California, Berkeley, Berkeley, CA 94720, USA.
出版信息
Dev Cell. 2021 May 17;56(10):1437-1451.e3. doi: 10.1016/j.devcel.2021.03.026. Epub 2021 Apr 19.
Adipose tissue mass and adiposity change throughout the lifespan. During aging, while visceral adipose tissue (VAT) tends to increase, peripheral subcutaneous adipose tissue (SAT) decreases significantly. Unlike VAT, which is linked to metabolic diseases, including type 2 diabetes, SAT has beneficial effects. However, the molecular details behind the aging-associated loss of SAT remain unclear. Here, by comparing scRNA-seq of total stromal vascular cells of SAT from young and aging mice, we identify an aging-dependent regulatory cell (ARC) population that emerges only in SAT of aged mice and humans. ARCs express adipose progenitor markers but lack adipogenic capacity; they secrete high levels of pro-inflammatory chemokines, including Ccl6, to inhibit proliferation and differentiation of neighboring adipose precursors. We also found Pu.1 to be a driving factor for ARC development. We identify an ARC population and its capacity to inhibit differentiation of neighboring adipose precursors, correlating with aging-associated loss of SAT.
脂肪组织质量和肥胖程度在整个生命周期中都在发生变化。随着衰老的发生，内脏脂肪组织（VAT）往往会增加，而外周皮下脂肪组织（SAT）则会显著减少。与与 2 型糖尿病等代谢疾病相关的 VAT 不同，SAT 具有有益的作用。然而，与衰老相关的 SAT 丧失的分子细节仍不清楚。在这里，通过比较来自年轻和衰老小鼠 SAT 的总基质血管细胞的 scRNA-seq，我们鉴定出一种仅在衰老小鼠和人类的 SAT 中出现的衰老依赖性调节细胞（ARC）群体。ARC 表达脂肪祖细胞标记物，但缺乏成脂能力；它们分泌高水平的促炎趋化因子，包括 Ccl6，以抑制邻近脂肪前体的增殖和分化。我们还发现 Pu.1 是 ARC 发育的驱动因素。我们鉴定出一种 ARC 群体及其抑制邻近脂肪前体分化的能力，与衰老相关的 SAT 丧失相关。
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