Zervas Athanasios, Chrousos George, Livadas Sarantis
Endocrine Unit, Athens Medical Centre, Athens, Greece.
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University Research Institute of Maternal and Child Health and Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, Athens, Greece.
Endocr Connect. 2021 May 19;10(5):R189-R199. doi: 10.1530/EC-20-0615.
'Snow White and the Seven Dwarfs', a fairytale that is widely known across the Western world, was originally written by the Brothers Grimm, and published in 1812 as 'Snow White'. Though each dwarf was first given an individual name in the 1912 Broadway play, in Walt Disney's 1937 film 'Snow White and the Seven Dwarfs', they were renamed, and the dwarfs have become household names. It is well known that myths, fables, and fairytales, though appearing to be merely children's tales about fictional magical beings and places, have, more often than not, originated from real facts. Therefore, the presence of the seven brothers with short stature in the story is, from an endocrinological point of view, highly intriguing, in fact, thrilling. The diversity of the phenotypes among the seven dwarfs is also stimulating, although puzzling. We undertook a differential diagnosis of their common underlying disorder based on the original Disney production's drawings and the unique characteristics of these little gentlemen, while we additionally evaluated several causes of short stature and, focusing on endocrine disorders that could lead to these clinical features among siblings, we have, we believe, been able to reveal the underlying disease depicted in this archetypal tale.
《白雪公主和七个小矮人》是一部在西方世界广为人知的童话,最初由格林兄弟创作,并于1812年以《白雪公主》为名出版。尽管每个小矮人在1912年的百老汇剧中首次被赋予了各自的名字,但在沃尔特·迪斯尼1937年的电影《白雪公主和七个小矮人》中,他们被重新命名,这些小矮人也因此家喻户晓。众所周知,神话、寓言和童话虽然看似仅仅是关于虚构的神奇生物和地方的儿童故事,但往往都源于真实事件。因此,从内分泌学的角度来看,故事中七个身材矮小的兄弟的存在极具吸引力,事实上,令人兴奋。七个小矮人之间表型的多样性也很有意思,尽管令人困惑。我们根据迪斯尼原版动画中的绘图以及这些小先生们的独特特征,对他们共同的潜在疾病进行了鉴别诊断,同时我们还评估了几种导致身材矮小的原因,并着重关注了可能导致兄弟姐妹出现这些临床特征的内分泌疾病,我们相信,我们已经能够揭示这个经典故事中所描绘的潜在疾病。