Li Xiaobo, Zhou Guangyu, Tian Xiaobo, Chen Fei, Li Guoyao, Ding Yipeng
Department of General Practice, People's Hospital of Wanning, Wanning, 571500, Hainan, China.
Department of Nursing, People's Hospital of Wanning, Wanning, 571500, Hainan, China.
BMC Pulm Med. 2021 Apr 20;21(1):129. doi: 10.1186/s12890-021-01498-3.
Chronic obstructive pulmonary disease (COPD) is characterized by incomplete reversible airflow limitation and chronic inflammatory response lesions. This study mainly explored whether FGFR2 and MGAT5 polymorphisms affected the risk of COPD in the Chinese people.
Five variants in FGFR2 and MGAT5 were chosen and genotyped using Agena MassARRAY platform from 315 COPD patients and 314 healthy controls. The correlation of FGFR2 and MGAT5 with COPD susceptibility was evaluated with odds ratio (OR) and 95% confidence interval (CI) via logistic regression.
We found rs2420915 enhanced the risk of COPD, while rs6430491, rs2593704 reduced the susceptibility of COPD (p < 0.05). Rs2420915 could promote the incidence of COPD in the elderly and nonsmokers. Rs1907240 and rs2257129 also increased the susceptibility to COPD in nonsmokers (p < 0.05). MGAT5-rs2593704 played a protective role in COPD development in different subgroups (age ≤ 70, male, smokers, and individuals with BMI ≤ 24 kg/m). Meanwhile, rs6430491 was linked with a lower risk of COPD in nonsmoking and BMI ≤ 24 kg/m subgroups.
We concluded that FGFR2 and MGAT5 genetic polymorphisms are correlated with the risk of COPD in the Chinese people. These data underscored the important role of FGFR2 and MGAT5 gene in the occurrence of COPD and provided new biomarkers for COPD treatment.
NA.
慢性阻塞性肺疾病（COPD）的特征是气流受限不完全可逆以及慢性炎症反应性病变。本研究主要探讨FGFR2和MGAT5基因多态性是否影响中国人患COPD的风险。
选择FGFR2和MGAT5中的五个变异位点，使用Agena MassARRAY平台对315例COPD患者和314例健康对照进行基因分型。通过逻辑回归，用比值比（OR）和95%置信区间（CI）评估FGFR2和MGAT5与COPD易感性的相关性。
我们发现rs2420915增加了患COPD的风险，而rs6430491、rs2593704降低了COPD的易感性（p<0.05）。rs2420915可增加老年人和非吸烟者患COPD的发生率。Rs1907240和rs2257129也增加了非吸烟者患COPD的易感性（p<0.05）。MGAT5-rs2593704在不同亚组（年龄≤70岁、男性、吸烟者和BMI≤24 kg/m的个体）的COPD发展中起保护作用。同时，rs6430491与非吸烟且BMI≤24 kg/m亚组中较低的COPD风险相关。
我们得出结论，FGFR2和MGAT5基因多态性与中国人患COPD风险相关。这些数据强调了FGFR2和MGAT5基因在COPD发生中的重要作用，并为COPD治疗提供了新的生物标志物。
无。
