LINC01414/LINC00824 基因多态性与慢性阻塞性肺疾病易感性的关联。
LINC01414/LINC00824 genetic polymorphisms in association with the susceptibility of chronic obstructive pulmonary disease.
机构信息
Department of General Practice, Hainan General Hospital, #19, Xiuhua Road, Xiuying District, Haikou, 570311, Hainan, People's Republic of China.
出版信息
BMC Pulm Med. 2021 Jul 7;21(1):213. doi: 10.1186/s12890-021-01579-3.
OBJECTIVE
Chronic obstructive pulmonary disease (COPD) is a complicated multi-factor, multi-gene disease. Here, we aimed to assess the association of genetic polymorphisms in LINC01414/ LINC00824 and interactions with COPD susceptibility.
METHODS
Three single nucleotide polymorphisms (SNPs) in LINC01414/LINC00824 was genotyped by Agena MassARRAY platform among 315 COPD patients and 314 controls. Logistic analysis adjusted by age and gender were applied to estimate the genetic contribution of selected SNPs to COPD susceptibility.
RESULTS
LINC01414 rs699467 (OR = 0.73, 95% CI 0.56-0.94, p = 0.015) and LINC00824 rs7815944 (OR = 0.56, 95% CI 0.31-0.99, p = 0.046) might be protective factors for COPD occurrence, while LINC01414 rs298207 (OR = 2.88, 95% CI 1.31-6.31, p = 0.008) risk-allele was related to the increased risk of COPD in the whole population. Rs7815944 was associated with the reduced risk of COPD in the subjects aged > 70 years (OR = 0.29, p = 0.005). Rs6994670 (OR = 0.57, p = 0.007) contribute to a reduced COPD risk, while rs298207 (OR = 7.94, p = 0.009) was related to a higher susceptibility to COPD at age ≤ 70 years. Rs298207 (OR = 2.54, p = 0.043) and rs7815944 (OR = 0.43, p = 0.028) variants was associated COPD risk among males. Rs7815944 (OR = 0.16, p = 0.031) was related to the reduced susceptibility of COPD in former smokers. Moreover, the association between rs298207 genotype and COPD patients with dyspnea was found (OR = 0.50, p = 0.016), and rs7815944 was related to COPD patients with wheezing (OR = 0.22, p = 0.008).
CONCLUSION
Our finding provided further insights into LINC01414/LINC00824 polymorphisms at risk of COPD occurrence and accumulated evidence for the genetic susceptibility of COPD.
目的
慢性阻塞性肺疾病（COPD）是一种复杂的多因素、多基因疾病。本研究旨在评估 LINC01414/LINC00824 中遗传多态性与 COPD 易感性的关联。
方法
采用 Agena MassARRAY 平台对 315 例 COPD 患者和 314 例对照者的 LINC01414/LINC00824 中的 3 个单核苷酸多态性（SNP）进行基因分型。采用经年龄和性别调整的 logistic 分析来估计所选 SNP 对 COPD 易感性的遗传贡献。
结果
LINC01414 rs699467（OR=0.73，95%CI 0.56-0.94，p=0.015）和 LINC00824 rs7815944（OR=0.56，95%CI 0.31-0.99，p=0.046）可能是 COPD 发生的保护因素，而 LINC01414 rs298207（OR=2.88，95%CI 1.31-6.31，p=0.008）的风险等位基因与全人群 COPD 风险增加相关。rs7815944 与>70 岁人群 COPD 发病风险降低相关（OR=0.29，p=0.005）。rs6994670（OR=0.57，p=0.007）有助于降低 COPD 风险，而 rs298207（OR=7.94，p=0.009）与≤70 岁人群 COPD 易感性增加相关。rs298207（OR=2.54，p=0.043）和 rs7815944（OR=0.43，p=0.028）与男性 COPD 风险相关。rs7815944（OR=0.16，p=0.031）与戒烟者 COPD 易感性降低有关。此外，还发现 rs298207 基因型与 COPD 呼吸困难患者有关（OR=0.50，p=0.016），rs7815944 与 COPD 喘息患者有关（OR=0.22，p=0.008）。
结论
本研究结果进一步阐明了 LINC01414/LINC00824 多态性与 COPD 发病风险的关系，为 COPD 的遗传易感性提供了更多证据。
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