核苷酸结合寡聚化结构域 1（NOD1）rs2075820（p.E266K）多态性与感染 cagPAI 阳性幽门螺杆菌的个体中的胃癌相关。
NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori.
机构信息
Human Genetics Program, Institute of Biomedical Sciences (ICBM), School of Medicine, University of Chile, 8380453, Santiago, Chile.
Department of Surgery, University of Chile Clinical Hospital, 8380456, Santiago, Chile.
出版信息
Biol Res. 2021 Apr 20;54(1):13. doi: 10.1186/s40659-021-00336-4.
BACKGROUND
Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TLR4, TLR5, NOD1 and NOD2 genes are associated with gastric cancer, in particular in individuals infected with H. pylori.
RESULTS
A case-control study of 297 gastric cancer patients and 300 controls was performed to assess the association of 17 polymorphisms. Analyses performed under the allele model did not find association with gastric cancer. However, NOD1 rs2075820 (p.E266K) showed association with intestinal-type gastric cancer among H. pylori infected subjects (OR = 2.69, 95% CI 1.41-5.13, p = 0.0026). The association was not statistically significant in diffuse-type gastric cancer cases (OR = 1.26, 95% CI 0.63-2.52, p = 0.51). When the analyses were performed in patients carrying H. pylori strains harboring the cag pathogenicity island (cagPAI), we noticed significant association with NOD1 rs2075820 (OR = 4.90, 95% CI 1.80-3.36, p = 0.0019), in particular for intestinal-type gastric cancer cases (OR = 7.16, 95% CI 2.40-21.33, p = 4.1 × 10) but not among diffuse-type gastric cancer cases (OR = 3.39, 95% CI 1.13-0.10, p = 0.03).
CONCLUSIONS
NOD1 rs2075820 increases the risk of intestinal-type gastric cancer among individuals infected with H. pylori, particularly in those harboring the cagPAI.
背景
幽门螺杆菌被包括 Toll 样受体 (TLR) 和核苷酸结合寡聚化结构域 (NOD)-样受体在内的病原体识别受体所识别，引发针对该细菌的固有免疫反应。本研究旨在评估 TLR2、TLR4、TLR5、NOD1 和 NOD2 基因的多态性是否与胃癌相关，特别是在感染幽门螺杆菌的个体中。
结果
对 297 例胃癌患者和 300 例对照进行了病例对照研究，以评估 17 种多态性与胃癌的关联。在等位基因模型下进行的分析未发现与胃癌相关。然而，在感染幽门螺杆菌的受试者中，NOD1 rs2075820 (p.E266K) 与肠型胃癌相关（OR=2.69，95%CI 1.41-5.13，p=0.0026）。在弥漫型胃癌病例中，该关联无统计学意义（OR=1.26，95%CI 0.63-2.52，p=0.51）。当在携带 cag 致病岛 (cagPAI) 的幽门螺杆菌菌株的患者中进行分析时，我们注意到 NOD1 rs2075820 与幽门螺杆菌感染显著相关（OR=4.90，95%CI 1.80-3.36，p=0.0019），特别是在肠型胃癌病例中（OR=7.16，95%CI 2.40-21.33，p=4.1×10），但在弥漫型胃癌病例中无显著相关性（OR=3.39，95%CI 1.13-0.10，p=0.03）。
结论
NOD1 rs2075820 增加了感染幽门螺杆菌的个体发生肠型胃癌的风险，尤其是在携带 cagPAI 的个体中。
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