不只是关闭和开启：解析一种机械感受器。

More Than Just Closed and Open: Unraveling a Mechanosensor.

机构信息

Biocenter and Rudolf-Virchow-Zentrum, Universität Würzburg, Haus D15, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.

出版信息

Trends Biochem Sci. 2021 Aug;46(8):623-625. doi: 10.1016/j.tibs.2021.04.002. Epub 2021 Apr 17.

DOI:10.1016/j.tibs.2021.04.002

Abstract

The bacterial mechanosensitive channel of small conductance (MscS) is a well-studied model of how mechanical forces from the membrane can be sensed by an embedded protein. A recent study by Zhang et al. visualizes how MscS behaves under membrane tension, entering a desensitized state when it loses all coordinated lipids.

摘要

细菌的小电导机械敏感通道（MscS）是研究如何通过嵌入蛋白感知来自膜的机械力的一个很好的模型。最近，Zhang 等人的研究直观地展示了 MscS 在膜张力下的行为，当它失去所有协调脂质时，会进入脱敏状态。