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减重手术后停用所有口服阿片类药物的可行性研究。

Feasibility study on elimination of all oral opioids following bariatric surgery.

机构信息

Department of Bariatric Surgery, Kaiser Permanente, South Sacramento Medical Center, Sacramento, California.

Department of Bariatric Surgery, Kaiser Permanente, South Sacramento Medical Center, Sacramento, California.

出版信息

Surg Obes Relat Dis. 2021 Jun;17(6):1069-1077. doi: 10.1016/j.soard.2021.03.003. Epub 2021 Mar 8.

Abstract

BACKGROUND

The bariatric population is at increased risk for developing chronic opioid dependence. The practice of prescribing oral opioids for analgesia in postoperative ambulatory settings is a known risk factor for developing chronic opioid dependence. The use of oral opioids following minimally invasive bariatric surgery may not be necessary.

OBJECTIVES

To determine whether there is any measurable impact on patient care metrics (length of stay, inpatient delta pain score, 30-day emergency department presentations, and 30-day readmissions) when eliminating the use of oral opioids for postoperative analgesia following laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (SG).

SETTING

Retrospective cohort study of data collected at a single bariatric center.

METHODS

A cohort of 189 consecutive patients received oral opioids in the immediate postoperative setting, in addition to a prescription for oral opioids at the time of discharge following LRYGB and SG. A second cohort of 136 consecutive patients did not receive oral opioids at any point following surgery. A descriptive bivariate analysis was performed to examine the relationships between cohort characteristics and treatment type. A multivariable linear regression analysis and a logistic regression analysis were conducted to assess the association of treatment type with clinical outcomes of interest.

RESULTS

The oral opioid-free cohort received significantly fewer morphine milligram equivalents during their postoperative hospital admission (P < .001). There were no differences in lengths of stay, 30-day emergency department presentations, or 30-day readmissions. Patients in the oral opioid-free cohort reported lower average delta pain scores (P < .001).

CONCLUSION

Eliminating the use of oral opioids for analgesia following LRYGB and SG does not negatively impact patient care metrics and may improve patient-reported analgesia, as reflected by a significant difference in delta pain scores averages. Elimination of oral opioids from all postoperative analgesia regimens is feasible.

摘要

背景

肥胖人群发生慢性阿片类药物依赖的风险增加。在门诊环境下开具口服阿片类药物进行镇痛的做法是导致慢性阿片类药物依赖的已知危险因素。微创减肥手术后使用口服阿片类药物可能并非必需。

目的

确定在腹腔镜 Roux-en-Y 胃旁路术(LRYGB)和腹腔镜袖状胃切除术(SG)后消除术后口服阿片类药物镇痛时,对患者护理指标(住院时间、住院期间 delta 疼痛评分、30 天内急诊就诊和 30 天内再入院)是否有任何可衡量的影响。

设置

在单一个减肥中心收集的数据进行回顾性队列研究。

方法

一组 189 例连续患者在 LRYGB 和 SG 后除了出院时开口服阿片类药物处方外,在术后即刻还接受了口服阿片类药物治疗。另一组 136 例连续患者在手术后任何时候都没有服用过口服阿片类药物。进行描述性双变量分析以检查队列特征和治疗类型之间的关系。进行多变量线性回归分析和逻辑回归分析,以评估治疗类型与感兴趣的临床结果之间的关联。

结果

无口服阿片类药物组在术后住院期间接受的吗啡毫克当量明显减少(P <.001)。住院时间、30 天内急诊就诊或 30 天内再入院无差异。无口服阿片类药物组患者报告的平均 delta 疼痛评分较低(P <.001)。

结论

在 LRYGB 和 SG 后消除口服阿片类药物镇痛不会对患者护理指标产生负面影响,并且可能改善患者报告的镇痛效果,这反映在 delta 疼痛评分平均值的显著差异上。从所有术后镇痛方案中消除口服阿片类药物是可行的。

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