A balancing act between primate lentiviruses and their receptor.
作者信息
Ohainle Molly, Malik Harmit S
机构信息
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;
出版信息
Proc Natl Acad Sci U S A. 2021 May 18;118(20). doi: 10.1073/pnas.2104741118.
Abstract
摘要
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A balancing act between primate lentiviruses and their receptor.灵长类慢病毒与其受体之间的平衡行为。
Proc Natl Acad Sci U S A. 2021 May 18;118(20). doi: 10.1073/pnas.2104741118.
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CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses.CD4 受体多样性代表了一种古老的保护机制，可抵御灵长类慢病毒。
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Trends Microbiol. 2020 Aug;28(8):655-667. doi: 10.1016/j.tim.2020.03.007. Epub 2020 May 14.
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A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV).黑猩猩 CD4 上的糖蛋白盾牌可防止灵长类慢病毒（HIV/SIV）感染。
Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11460-11469. doi: 10.1073/pnas.1813909116. Epub 2019 May 21.
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CD4 receptor diversity in chimpanzees protects against SIV infection.在黑猩猩体内，CD4 受体多样性可防止 SIV 感染。
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3229-3238. doi: 10.1073/pnas.1821197116. Epub 2019 Feb 4.
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HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.HIV-1 Env 三聚体通过非对称中间体打开，其中单个原聚体采用不同的构象。
Elife. 2018 Mar 21;7:e34271. doi: 10.7554/eLife.34271.
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Trans-species polymorphism in humans and the great apes is generally maintained by balancing selection that modulates the host immune response.人类和大猩猩之间的跨物种多态性通常通过调节宿主免疫反应的平衡选择来维持。
Hum Genomics. 2015 Sep 4;9(1):21. doi: 10.1186/s40246-015-0043-1.
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Footprints of ancient-balanced polymorphisms in genetic variation data from closely related species.来自近缘物种遗传变异数据中古代平衡多态性的印记。
Evolution. 2015 Feb;69(2):431-46. doi: 10.1111/evo.12567. Epub 2015 Jan 16.
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Positive selection of primate genes that promote HIV-1 replication.促进 HIV-1 复制的灵长类动物基因的正选择。
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New Phytol. 2014 Jan;201(1):45-56. doi: 10.1111/nph.12441. Epub 2013 Aug 19.
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Host gene evolution traces the evolutionary history of ancient primate lentiviruses.宿主基因进化追踪了古代灵长类慢病毒的进化历史。
Philos Trans R Soc Lond B Biol Sci. 2013 Aug 12;368(1626):20120496. doi: 10.1098/rstb.2012.0496. Print 2013 Sep 19.
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