First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine.
Medicine (Baltimore). 2021 Apr 23;100(16):e25544. doi: 10.1097/MD.0000000000025544.
Tension-type headache (TTH) is the most common form of primary headache with high prevalence, which affects the quantity of life seriously. The pharmacological treatment of TTH is not the most effective. Meanwhile, complementary therapies and alternative therapies play an essential role in the treatment of TTH, and there is an absence of comparison between various interventions. Therefore, we propose the network meta-analysis protocol to compare the efficacy and safety of various complementary therapies and alternative therapies for TTH.
From the beginning to February 2021, we will search the database to collect randomized controlled trials of complementary and alternative therapies for TTH. Two researchers will be responsible for screening retrieve documents, extracting data. The risk of bias will be assessed based on the Cochrane bias risk tool. We will use STATA16.0 and WinBUGS1.4.3 for paired meta-analysis and Bayesian network meta-analysis. The quality of evidence will be assessed using the grading of recommendations assessment development and evaluation.
This study will compare and rank the efficacy and safety of various complementary and alternative treatments for TTH.
This study will provide more extensive evidence for the complementary and alternative therapies of TTH. We expect to assist clinicians and patients in choosing the optimum treatment.
INPLASY202130088.
紧张型头痛（TTH）是最常见的原发性头痛，其患病率较高，严重影响生活质量。TTH 的药物治疗效果并不理想。同时，补充疗法和替代疗法在 TTH 的治疗中起着重要作用，各种干预措施之间缺乏比较。因此，我们提出了网络荟萃分析方案，以比较 TTH 各种补充疗法和替代疗法的疗效和安全性。
从开始到 2021 年 2 月，我们将搜索数据库以收集 TTH 的补充和替代疗法的随机对照试验。两位研究人员将负责筛选检索文件并提取数据。根据 Cochrane 偏倚风险工具评估偏倚风险。我们将使用 STATA16.0 和 WinBUGS1.4.3 进行配对荟萃分析和贝叶斯网络荟萃分析。使用推荐评估、制定与评价分级（Grading of Recommendations Assessment, Development and Evaluation，GRADE）评估证据质量。
本研究将比较和排名 TTH 各种补充和替代治疗的疗效和安全性。
本研究将为 TTH 的补充和替代疗法提供更广泛的证据。我们希望能帮助临床医生和患者选择最佳的治疗方法。
INPLASY202130088。
