Capitaine Y, Roche B, Wiesner L, Hahnloser P
Clinique médicale, Hôpital cantonal, Fribourg.
Schweiz Med Wochenschr. 1988 May 28;118(21):817-20.
42 cases of chronic pancreatitis treated between 1976 and 1986, presenting 0.2% of all patients seen at the surgical clinic in the same period, have been reviewed. 37 patients (88%) were alcoholics and the prevalence of males was 83%. -Study of dietary habits showed a very high alcohol intake of 135.3 g alcohol per day, contrasting with the control group's alcohol consumption of 44.9 g per day. Alcohol intake calculated per life of patient with chronic pancreatitis represented 850.4 kg, whereas the control group consumed 344.1 kg (beer and wine). -Patients with chronic pancreatitis had started excessive alcohol consumption at an average age of 18 +/- 2 years and continued for an average of 18.0 +/- 1 years. These data correspond to zone A, i.e. Southern Europe. The evolution was analyzed with regard to persistence or cessation of alcoholism. Repeated attacks of chronic pancreatitis were seen in both groups. Patients abstaining from alcohol had only one attack during an average period of 10 years. Painful recurrences after surgery seem to be more frequent with persistent alcoholism (4 out of 5 patients), whereas in 15 patients without alcoholism they were observed only 3 times. -This shows that alcoholism remains the main factor in the natural history and evolution of chronic pancreatitis.
回顾了1976年至1986年间治疗的42例慢性胰腺炎患者，占同期外科门诊所见所有患者的0.2%。37例患者（88%）为酗酒者，男性患病率为83%。饮食习惯研究显示，慢性胰腺炎患者每日酒精摄入量非常高，达135.3克，而对照组每日酒精摄入量为44.9克。按慢性胰腺炎患者一生计算的酒精摄入量为850.4千克，而对照组为344.1千克（啤酒和葡萄酒）。慢性胰腺炎患者开始过度饮酒的平均年龄为18±2岁，持续时间平均为18.0±1年。这些数据符合A区，即南欧的情况。分析了酗酒持续或戒断情况下的病情发展。两组均出现慢性胰腺炎反复发作。戒酒的患者在平均10年期间仅发作一次。持续性酗酒患者术后疼痛复发似乎更频繁（5例患者中有4例），而15例无酗酒的患者仅观察到3次疼痛复发。这表明酗酒仍然是慢性胰腺炎自然病史和病情发展的主要因素。
