Moriyama Kengo, Kishimoto Noriaki, Shiina Yutaka, Urata Nana, Masuda Yumi, Oda Kanae, Yamada Chizumi, Takashimizu Shinji, Kubo Akira, Nishizaki Yasuhiro
Department of Clinical Health Science, Tokai University School of Medicine, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji, Tokyo 192-0032, Japan.
Department of Clinical Health Science, Tokai University School of Medicine, 1-2-5 Yoyogi, Shibuya-ku, Tokyo 151-0053, Japan.
J Clin Biochem Nutr. 2021 Mar;68(2):164-168. doi: 10.3164/jcbn.20-95. Epub 2020 Oct 13.
Results from a recent study indicate that a higher level of oleic acid/stearic acid ratio was associated with metabolically unhealthy obesity. This was further validated in cross-sectional and interventional studies; however, this was not extensively studied in a non-obese population. We recruited 260 Japanese subjects with serum free fatty acid profiles undergoing anti-aging health examinations. The determinants for oleic acid/stearic acid ratio were investigated using multiple regression analyses. To compare different markers, the subjects were classified based on oleic acid/stearic acid ratio and the combination of oleic acid/stearic acid ratio and triglyceride levels. The oleic acid/stearic acid ratio exhibited a positive correlation with the logmatic transformed triglyceride/high-density lipoprotein cholesterol ratio and the fasting triglycerides-glucose index, both of which were used as markers for insulin resistance. Multiple regression analyses revealed that the triglyceride/high-density lipoprotein cholesterol ratio and fasting triglyceride-glucose index were positively associated with the oleic acid/stearic acid ratio. Most markers were the worst in the highest triglyceride group in both oleic acid/stearic acid groups. In addition, most markers were worse in high oleic acid/stearic acid ratio group than low group. In conclusion, oleic acid/stearic acid ratio might be a useful marker for insulin resistance in non-obese Japanese subjects.
最近一项研究的结果表明，较高水平的油酸/硬脂酸比值与代谢不健康型肥胖有关。这在横断面研究和干预性研究中得到了进一步验证；然而，在非肥胖人群中尚未对此进行广泛研究。我们招募了260名接受抗衰老健康检查且有血清游离脂肪酸谱的日本受试者。使用多元回归分析研究了油酸/硬脂酸比值的决定因素。为了比较不同指标，根据油酸/硬脂酸比值以及油酸/硬脂酸比值与甘油三酯水平的组合对受试者进行分类。油酸/硬脂酸比值与经对数转换的甘油三酯/高密度脂蛋白胆固醇比值以及空腹甘油三酯 - 葡萄糖指数呈正相关，这两个指标均用作胰岛素抵抗的标志物。多元回归分析显示，甘油三酯/高密度脂蛋白胆固醇比值和空腹甘油三酯 - 葡萄糖指数与油酸/硬脂酸比值呈正相关。在两个油酸/硬脂酸组中，大多数指标在甘油三酯水平最高的组中最差。此外，在高油酸/硬脂酸比值组中，大多数指标比低比值组更差。总之，油酸/硬脂酸比值可能是日本非肥胖受试者胰岛素抵抗的一个有用标志物。
