Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
University of Hawaii Cancer Center, Honolulu, Hawaii 96813, United States.
Sci Rep. 2016 Jun 27;6:28418. doi: 10.1038/srep28418.
Increasing evidences support that metabolically healthy obese (MHO) is a transient state. However, little is known about the early markers associated with the development of metabolic abnormalities in MHO individuals. Serum free fatty acids (FFAs) profile is highlighted in its association with obesity-related insulin resistance, type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). To examine the association of endogenous fatty acid metabolism with future development of metabolic abnormalities in MHO individuals, we retrospectively analyzed 24 [product FFA]/[precursor FFA] ratios in fasting sera and clinical data from 481 individuals who participated in three independent studies, including 131 metabolic healthy subjects who completed the 10-year longitudinal Shanghai Diabetes Study (SHDS), 312 subjects cross-sectionally sampled from the Shanghai Obesity Study (SHOS), and 38 subjects who completed an 8-week very low carbohydrate diet (VLCD) intervention study. Results showed that higher baseline level of oleic acid/stearic acid (OA/SA), and lower levels of stearic acid/palmitic acid (SA/PA) and arachidonic acid/dihomo-γ-linolenic acid (AA/DGLA) ratios were associated with higher rate of MHO to MUO conversion in the longitudinal SHDS. Further, the finding was validated in the cross-sectional and interventional studies. This panel of FFA ratios could be used for identification and early intervention of at-risk obese individuals.
越来越多的证据支持代谢健康型肥胖（MHO）是一种短暂的状态。然而，对于与 MHO 个体代谢异常发展相关的早期标志物知之甚少。血清游离脂肪酸（FFA）谱因其与肥胖相关的胰岛素抵抗、2 型糖尿病（T2DM）和心血管疾病（CVD）有关而备受关注。为了研究内源性脂肪酸代谢与 MHO 个体代谢异常发展的关系，我们回顾性分析了来自三个独立研究的 481 名参与者的空腹血清中 24 种[产物 FFA]/[前体 FFA] 比值和临床数据，这些参与者包括完成了 10 年上海糖尿病研究（SHDS）的 131 名代谢健康受试者、从上海肥胖研究（SHOS）中横向抽样的 312 名受试者和完成了 8 周极低碳水化合物饮食（VLCD）干预研究的 38 名受试者。结果表明，基线油酸/硬脂酸（OA/SA）比值较高，而硬脂酸/棕榈酸（SA/PA）和花生四烯酸/二高-γ-亚麻酸（AA/DGLA）比值较低与 SHDS 中 MHO 向 MUO 转化的更高比率相关。此外，这一发现在横断面和干预研究中得到了验证。这组 FFA 比值可用于识别和对高危肥胖个体进行早期干预。
