Worku Misganaw Gebrie
Department of Human Anatomy, University of Gondar, College of Medicine and Health Science, School of Medicine, Gondar, Ethiopia.
Stem Cells Cloning. 2021 Apr 12;14:3-7. doi: 10.2147/SCCAA.S304887. eCollection 2021.
There is numerous evidence for the presence of stem cells, which is important for the treatment of a wide variety of disease conditions. Stem cells have a great therapeutic effect on different degenerative diseases through the development of specialized cells. Embryonic stem (ES) cells are derived from preimplantation embryos, which have a natural karyotype. This cell has the capacity of proliferation indefinitely and undifferentiated. Stem cells are very crucial for the treatment of different chronic and degenerative diseases. For instance, stem cell clinical trials have been done for ischemic heart disease. Also, the olfactory cells for spinal cord lesions and human fetal pancreatic cells for diabetes mellitus are the other clinical importance of stem cell therapy. Extracellular matrix (ECM) and other environmental factors influence the fate and activity of stem cells.
有大量证据表明干细胞的存在，这对治疗多种疾病状况很重要。干细胞通过分化为特定细胞，对不同的退行性疾病具有巨大的治疗作用。胚胎干细胞（ES细胞）来源于植入前胚胎，具有天然的核型。这种细胞具有无限增殖和未分化的能力。干细胞对治疗不同的慢性和退行性疾病非常关键。例如，已经针对缺血性心脏病进行了干细胞临床试验。此外，用于脊髓损伤的嗅细胞和用于糖尿病的人胎儿胰腺细胞也是干细胞治疗的其他临床意义所在。细胞外基质（ECM）和其他环境因素会影响干细胞的命运和活性。
