Dayem Ahmed Abdal, Choi Hye Yeon, Yang Gwang-Mo, Kim Kyeongseok, Saha Subbroto Kumar, Kim Jin-Hoi, Cho Ssang-Goo
Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul, Korea.
Biotechnol J. 2016 Dec;11(12):1550-1560. doi: 10.1002/biot.201600453. Epub 2016 Oct 31.
Tissue regeneration could offer therapeutic advantages for individuals experiencing organ or tissue damage. Recently, advances in nanotechnology have provided various nanomaterials, with a wide range of applications, for modulating stem cell behavior and for further therapeutic applications in tissue regeneration. Defects in cell proliferation and differentiation, a low mechanical strength of scaffolds, and inefficient production of factors that are essential for stem cell differentiation are the current challenges in tissue regeneration. This review provides a brief explanation about the link between nanotechnology and tissue engineering, highlighting the current literature about the interaction between nanoparticles (NPs) and stem cells, the promotional effect of NPs on stem cell differentiation into various lineages, and their possible therapeutic applications. We also tried to describe the mechanism through which NPs regulate the spatial-temporal release and kinetics of vital growth and differentiation factors, enhance stem cell differentiation, and improve culture conditions for in vivo tissue regeneration. The field of nanotechnology is promising and provides novel nanomaterials and methods with valuable clinical applications in the regenerative medicine. Understanding the mechanism, as well as the toxic effects of NPs in stem cell biology will undoubtedly provide valuable insight into their clinical application in the regenerative medicine.
组织再生可为遭受器官或组织损伤的个体带来治疗优势。近年来，纳米技术的进展提供了各种具有广泛应用的纳米材料，用于调节干细胞行为以及在组织再生中进一步的治疗应用。细胞增殖和分化缺陷、支架机械强度低以及干细胞分化所必需的因子产生效率低下是目前组织再生面临的挑战。本综述简要解释了纳米技术与组织工程之间的联系，重点介绍了当前有关纳米颗粒（NPs）与干细胞相互作用、NPs对干细胞向各种谱系分化的促进作用及其可能的治疗应用的文献。我们还试图描述NPs调节重要生长和分化因子的时空释放及动力学、增强干细胞分化并改善体内组织再生培养条件的机制。纳米技术领域前景广阔，为再生医学提供了具有重要临床应用价值的新型纳米材料和方法。了解NPs在干细胞生物学中的作用机制以及毒性作用无疑将为其在再生医学中的临床应用提供有价值的见解。
