Cen Juan, Zhang Yichen, Bai Yindu, Ma Shenqian, Zhang Chuan, Jin Lin, Duan Shaofeng, Du Yanan, Guo Yuqi
Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China.
Key Laboratory of Natural Medicine and Immune Engineering, School of Pharmacy, Henan University, Kaifeng, 475001, China.
Mater Today Bio. 2022 Aug 8;16:100389. doi: 10.1016/j.mtbio.2022.100389. eCollection 2022 Dec.
Endometrial damage is an important factor leading to infertility and traditional conventional treatments have limited efficacy. As an emerging technology in recent years, stem cell therapy has provided new hope for the treatment of this disease. By comparing the advantages of stem cells from different sources, it is believed that menstrual blood endometrial stem cells have a good application prospect as a new source of stem cells. However, the clinical utility of stem cells is still limited by issues such as colonization rates, long-term efficacy, tumor formation, and storage and transportation. This paper summarizes the mechanism by which stem cells repair endometrial damage and clarifies the material basis of their effects from four aspects: replacement of damaged sites, paracrine effects, interaction with growth factors, and other new targets. According to the pathological characteristics and treatment requirements of intrauterine adhesion (IUA), the research work to solve the above problems from the aspects of functional bioscaffold preparation and multi-functional platform construction is also summarized. From the perspective of scaffold materials and component functions, this review will provide a reference for comprehensively optimizing the clinical application of stem cells.
子宫内膜损伤是导致不孕的重要因素，传统常规治疗疗效有限。干细胞治疗作为近年来新兴的技术，为该病的治疗带来了新希望。通过比较不同来源干细胞的优势，认为月经血子宫内膜干细胞作为一种新的干细胞来源具有良好的应用前景。然而，干细胞的临床应用仍受定植率、长期疗效、肿瘤形成以及储存运输等问题的限制。本文总结了干细胞修复子宫内膜损伤的机制，并从受损部位替代、旁分泌作用、与生长因子相互作用以及其他新靶点四个方面阐明了其作用的物质基础。根据宫腔粘连（IUA）的病理特征和治疗需求，还总结了从功能生物支架制备和多功能平台构建等方面解决上述问题的研究工作。从支架材料和组件功能的角度，本综述将为全面优化干细胞的临床应用提供参考。
