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新冠病毒引发的儿童1型糖尿病起病时的糖尿病酮症酸中毒:一例原始病例报告

Diabetic Ketoacidosis at Onset of Pediatric Type-1 Diabetes Triggered by Covid-19: An Original Case Report.

作者信息

Benyakhlef Salma, Abdellaoui Wahiba, Tahri Abir, Rouf Siham, Latrech Hanane

机构信息

Department of Diabetology and Endocrinology, Mohammed VI University Hospital, Mohamed I University, Oujda, MAR.

Department of Epidemiology, Clinical Research and Public Health, Mohamed I University, Oujda, MAR.

出版信息

Cureus. 2021 Mar 17;13(3):e13958. doi: 10.7759/cureus.13958.

Abstract

During the course of this year, scientific research has revolved around coronavirus disease 2019 (COVID-19), with much uncertainty surrounding its pathogenesis, complications, and mortality as well as limited pediatric evidence. The exact relationship between COVID-19 and new-onset type 1 diabetes, especially in children, remains an unresolved issue. Our case exhibited a unique presentation of diabetic ketoacidosis (DKA) triggering COVID-19 diagnosis at this age. A three-year-old Moroccan boy was admitted with a history of acute dyspnea accompanied by vomiting and weight loss, leading to a diagnosis of DKA. However, evident respiratory distress signs did not disappear, even though glycemic levels were normalized and acidosis resolved. The boy subsequently tested positive for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), with specific biological and radiological findings. Our clinical case potentially augmented the global registry of COVID-19-related diabetes (CoviDiab project) cases and provides a basis for further studies that seek to elucidate the correlation between new-onset type 1 diabetes and SARS-CoV-2 in the pediatric population.

摘要

在今年期间,科学研究主要围绕2019冠状病毒病(COVID-19)展开,其发病机制、并发症、死亡率存在诸多不确定性,儿科方面的证据也有限。COVID-19与新发1型糖尿病的确切关系,尤其是在儿童中的关系,仍是一个未解决的问题。我们的病例展示了糖尿病酮症酸中毒(DKA)在这个年龄段引发COVID-19诊断的独特表现。一名三岁的摩洛哥男孩因急性呼吸困难病史入院,伴有呕吐和体重减轻,诊断为DKA。然而,尽管血糖水平恢复正常且酸中毒得到缓解,但明显的呼吸窘迫体征并未消失。该男孩随后SARS-CoV-2(严重急性呼吸综合征冠状病毒2)检测呈阳性,伴有特定的生物学和影像学表现。我们的临床病例可能增加了全球COVID-19相关糖尿病(CoviDiab项目)病例登记,并为进一步研究提供了基础,这些研究旨在阐明儿科人群中新发1型糖尿病与SARS-CoV-2之间的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63dc/8052212/d5abc66cca63/cureus-0013-00000013958-i01.jpg

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