Ting Ka Ka, Coleman Paul, Zhao Yang, Vadas Mathew A, Gamble Jennifer R
Centre for the Endothelium Vascular Biology Program Centenary Institute, The University of Sydney, Sydney, New South Wales, Australia.
Vasc Biol. 2021 Jan 12;3(1):R35-R47. doi: 10.1530/VB-20-0013. eCollection 2021.
Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic diseases such as diabetes, obesity and atherosclerosis. Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases.
细胞衰老现在被认为是衰老的标志之一。在此，我们研究了血管内皮细胞衰老的当前研究结果及其对与年龄相关的血管疾病的影响。内皮细胞衰老可导致全身代谢变化，这表明衰老与糖尿病、肥胖症和动脉粥样硬化等慢性疾病有关。衰老细胞裂解剂，即消除衰老细胞的药物，为控制这些慢性疾病提供了新的治疗策略。
