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基于MIDAS和OTCims平台的欧洲过敏性鼻炎药物治疗的异质性。

Heterogeneity of the pharmacologic treatment of allergic rhinitis in Europe based on MIDAS and OTCims platforms.

作者信息

Bousquet Jean, Schröder-Bernhardi Detlef, Bachert Claus, Canonica G Walter, Cardona Victoria, Costa Elisio M, Czarlewski Wienczyslawa, Devillier Philippe, Fonseca Joao A, Klimek Ludger, Kuna Piotr, Lourenco Olga, Mullol Joaquim, Pfaar Oliver, Pham-Thi Nhân, Samolinski Boleslaw, Saueressig Julia, Scadding Glenis K, Stroh Ann-Kathrin, Scheire Sophie, Van Ganse Eric, Zuberbier Torsten

机构信息

Charité Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Department of Dermatology and Allergy, Comprehensive Allergy Center, Berlin Institute of Health, Berlin, Germany.

出版信息

Clin Exp Allergy. 2021 Aug;51(8):1033-1045. doi: 10.1111/cea.13884. Epub 2021 May 11.

Abstract

BACKGROUND

The practice of allergology varies widely between countries, and the costs and sales for the treatment of rhinitis differ depending on practices and health systems. To understand these differences and their implications, the rhinitis market was studied in some of the EU countries.

METHODS

We conducted a pharmaco-epidemiological database analysis to assess the medications that were being prescribed for allergic rhinitis in the years 2016, 2017 and 2018. We used the IQVIA platforms for prescribed medicines (MIDAS Meaningful Integration of Data, Analytics and Services) and for OTC medicines (OTC International Market Tracking-OTCims). We selected the five most important markets in the EU (France, Germany, Italy, Poland and Spain).

RESULTS

Intranasal decongestants were excluded from the analyses because they are rarely prescribed for allergic rhinitis. For both Standard Units (SU) and costs, France is leading the other countries. In terms of SU, the four other countries are similar. For costs, Poland is lower than the three others. However, medication use differs largely. For 2018, in SU, intranasal corticosteroid is the first treatment in Poland (70.0%), France (51.3%), Spain (51.1%) and Germany (50.3%), whereas the Italian market is dominated by systemic antihistamines (41.4%) followed by intranasal corticosteroids (30.1%). Results of other years were similar.

DISCUSSION

There are major differences between countries in terms of rhinoconjunctivitis medication usage.

摘要

背景

各国过敏症学的实践差异很大,鼻炎治疗的成本和销售额因实践和卫生系统而异。为了解这些差异及其影响,对一些欧盟国家的鼻炎市场进行了研究。

方法

我们进行了药物流行病学数据库分析,以评估2016年、2017年和2018年用于过敏性鼻炎的药物。我们使用IQVIA平台获取处方药(MIDAS,数据、分析和服务的有意义整合)和非处方药(OTC国际市场跟踪-OTCims)。我们选择了欧盟五个最重要的市场(法国、德国、意大利、波兰和西班牙)。

结果

鼻用减充血剂被排除在分析之外,因为它们很少用于过敏性鼻炎的处方。无论是标准单位(SU)还是成本方面,法国都领先于其他国家。在SU方面,其他四个国家相似。在成本方面,波兰低于其他三个国家。然而,药物使用差异很大。2018年,在SU方面,鼻用皮质类固醇在波兰(70.0%)、法国(51.3%)、西班牙(51.1%)和德国(50.3%)是首要治疗药物,而意大利市场以全身性抗组胺药为主(41.4%),其次是鼻用皮质类固醇(30.1%)。其他年份的结果相似。

讨论

各国在鼻结膜炎药物使用方面存在重大差异。

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