Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Vakilabad Blvd, Mashhad, Iran.
Oral and Maxillofacial Disease Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Lasers Med Sci. 2021 Dec;36(9):1949-1956. doi: 10.1007/s10103-021-03310-4. Epub 2021 Apr 21.
This clinical trial aimed to compare the effects of low-level laser therapy (LLLT), Er,Cr;YSGG laser, and fluoride varnish, as compared to the placebo laser on decreasing dentin hypersensitivity (DH). This randomized, double-blinded clinical trial included 60 jaw quadrants in 24 patients who underwent periodontal surgery. The quadrants were randomly assigned to 4 groups and received treatments as follows. Group 1: LLLT with a combination of red and infrared wavelengths, group 2: Er,Cr:YSGG laser (0.25 W and 0.5 W), group 3: fluoride varnish, and group 4: placebo laser. The sensitivity response to the cold spray was recorded using visual analogue scale (VAS) at baseline, immediately, and 1 week post-treatment. The data were analyzed by repeated measures analysis at the significance level of P<0.05. There was a significant reduction in DH after treatment by low-level lasers, Er,Cr:YSGG laser, or fluoride varnish compared to the baseline data (P<0.05), but the placebo group displayed no significant alteration in DH (P=0.069). At 1 week, the VAS score in the Er,Cr:YSGG laser group was significantly lower than that of the LLLT (P= 0.043) and placebo (P<0.001) groups. Furthermore, the subjects who received fluoride varnish exhibited significantly lower DH compared with the placebo group (P = 0.023). Er,Cr:YSGG laser was the most effective strategy in dealing with DH, as it caused the greatest pain reduction over the study period and showed a significant superiority over LLLT and placebo groups. Alternatively, the application of fluoride varnish could be recommended for attenuating DH following periodontal surgery.
本临床试验旨在比较低水平激光疗法（LLLT）、Er,Cr;YSGG 激光和氟化物涂料与安慰剂激光在降低牙本质敏感（DH）方面的效果。这是一项随机、双盲临床试验，纳入了 24 名接受牙周手术的患者的 60 个颌骨象限。这些象限被随机分配到 4 个组，并接受以下治疗。第 1 组：红、红外波长组合的 LLLT，第 2 组：Er,Cr:YSGG 激光（0.25 W 和 0.5 W），第 3 组：氟化物涂料，第 4 组：安慰剂激光。使用视觉模拟量表（VAS）在基线、即刻和治疗后 1 周记录冷喷的敏感性反应。数据在 P<0.05 的显著性水平下采用重复测量分析进行分析。与基线数据相比，低水平激光、Er,Cr:YSGG 激光或氟化物涂料治疗后 DH 显著降低（P<0.05），但安慰剂组 DH 无明显变化（P=0.069）。在 1 周时，Er,Cr:YSGG 激光组的 VAS 评分明显低于 LLLT 组（P=0.043）和安慰剂组（P<0.001）。此外，接受氟化物涂料的受试者与安慰剂组相比，DH 明显降低（P = 0.023）。Er,Cr:YSGG 激光是治疗 DH 的最有效策略，因为它在整个研究期间引起的疼痛减轻最大，并且与 LLLT 和安慰剂组相比具有显著优势。或者，可以推荐使用氟化物涂料来减轻牙周手术后的 DH。
