色素性胆结石犬模型中总钙和游离离子钙增加。

Increased total and free ionized calcium in a canine model of pigment gallstones.

作者信息

Dawes L G, Nahrwold D L, Rege R V

机构信息

Department of Surgery, Northwestern University Medical School, Chicago, Ill.

出版信息

Surgery. 1988 Jul;104(1):86-90.

PMID:3388182

Abstract

It has been postulated that precipitation of calcium from bile is important in the formation and growth of pigment gallstones, since they contain large amounts of calcium. Therefore we studied biliary total calcium [( Ca]) and free ionized calcium [( Ca++]) concentrations in 12 dogs before and after 6 weeks of a methionine-deficient, high-cholesterol diet. In all dogs pigment gallstones and sludge formed while the animals were on the diet. Although gallbladder function--as assessed by biliary pH, total bile salt, and bile electrolyte concentrations--was minimally altered by the diet, both [Ca] and [Ca++] increased significantly, from 10.16 +/- 0.19 to 13.16 +/- 0.57 mmol/L and 3.02 +/- 0.07 to 3.76 +/- 0.17 mmol/L, respectively. The observed increases in calcium concentrations, and specifically in [Ca++], early during stone formation in this model would increase the likelihood that bile would become saturated with at least one calcium salt and support the hypothesis that calcium is important in pigment gallstone formation.

摘要

据推测，胆汁中钙的沉淀在色素胆结石的形成和生长过程中起着重要作用，因为色素胆结石含有大量的钙。因此，我们研究了12只狗在食用蛋氨酸缺乏、高胆固醇饮食6周前后的胆汁总钙（[Ca]）和游离离子钙（[Ca++]）浓度。在这些动物食用该饮食期间，所有狗都形成了色素胆结石和胆泥。尽管通过胆汁pH值、总胆汁盐和胆汁电解质浓度评估的胆囊功能受该饮食的影响极小，但[Ca]和[Ca++]均显著增加，分别从10.16±0.19 mmol/L增至13.16±0.57 mmol/L，以及从3.02±0.07 mmol/L增至3.76±0.17 mmol/L。在该模型中结石形成早期观察到的钙浓度增加，特别是[Ca++]的增加，会增加胆汁至少与一种钙盐饱和的可能性，并支持钙在色素胆结石形成中起重要作用这一假说。