Hematology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Diagnostic pathology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
J Clin Exp Hematop. 2021 Jun 5;61(2):93-96. doi: 10.3960/jslrt.20042. Epub 2021 Apr 20.
Acute fibrinous and organizing pneumonia (AFOP) is a rare acute lung injury featuring pathological intra-alveolar fibrin balls and organizing pneumonia without hyaline membranes or eosinophils. AFOP forms acute and subacute patterns; the former often has a poor prognosis, whereas the latter has better survival. Secondary hemophagocytic syndrome (HPS) is a cytokine-related and potentially lethal disorder induced by various diseases, and pulmonary involvement in HPS is not rare. However, to our knowledge, no report has addressed the association between secondary HPS and AFOP development. We report two cases of subacute AFOP following HPS in hematological malignancies.
急性纤维蛋白性和机化性肺炎（AFOP）是一种罕见的急性肺损伤，其特征为肺泡腔内有纤维蛋白球和机化性肺炎，而无透明膜或嗜酸性粒细胞。AFOP 可呈急性和亚急性表现；前者的预后通常较差，而后者的生存率较高。继发性噬血细胞综合征（HPS）是一种由多种疾病引起的细胞因子相关、潜在致命的疾病，HPS 肺部受累并不少见。然而，据我们所知，尚无报告探讨继发性 HPS 与 AFOP 发展之间的关联。我们报告了两例血液系统恶性肿瘤继发 HPS 后的亚急性 AFOP 病例。
