急性纤维蛋白性和机化性肺炎：两例病例报告及文献复习。
Acute fibrinous and organizing pneumonia: two case reports and literature review.
机构信息
Department of Respiratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Pudong, 200120, Shanghai, China.
Department of Pathology, Shanghai East Hospital, Tongji University School of Medicine, Pudong, 200120, Shanghai, China.
出版信息
BMC Pulm Med. 2019 Aug 5;19(1):141. doi: 10.1186/s12890-019-0861-3.
BACKGROUND
Acute fibrinous and organizing pneumonia (AFOP) is a very rare form of acute or subacute lung injury, which is characterized by patches of "fibrin balls" distributed within the alveoli. Given the lack of typical clinical manifestations, AFOP is often misdiagnosed as pneumonia, tuberculosis, etc. Definitive diagnosis is obtained from a lung biopsy. Corticosteroids are usually effective.
CASE PRESENTATION
We report two cases of patients with histopathological manifestations of AFOP, which were significantly improved after corticosteroid therapy. Previous reports of the clinical and pathological characteristics of AFOP were reviewed to improve clinicians' understanding of this disease.
CONCLUSIONS
Early identification and diagnosis are very important for AFOP treatment. The prognosis is acceptable after timely and effective treatment.
背景
急性纤维蛋白性和机化性肺炎（AFOP）是一种非常罕见的急性或亚急性肺损伤形式，其特征是肺泡内分布有“纤维蛋白球”斑块。由于缺乏典型的临床表现，AFOP 常被误诊为肺炎、肺结核等。明确诊断需要通过肺活检获得。皮质类固醇通常有效。
病例介绍
我们报告了两例具有 AFOP 组织病理学表现的患者，他们在皮质类固醇治疗后明显改善。回顾了以前关于 AFOP 的临床和病理特征的报告，以提高临床医生对这种疾病的认识。
结论
早期识别和诊断对 AFOP 治疗非常重要。及时有效的治疗后，预后是可以接受的。
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