肾小球滤过功能障碍与绝经后糖尿病中国女性的心脏不良重构有关。
Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women.
机构信息
Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
出版信息
Clin Interv Aging. 2021 Apr 14;16:603-609. doi: 10.2147/CIA.S306342. eCollection 2021.
BACKGROUND
Previous studies have showed that nephropathy was associated with cardiac structural changes and dysfunction among diabetic adults. However, information on the association of glomerular filtration dysfunction with the cardiac adverse remodeling is still limited in menopausal diabetic women. Therefore, we investigated whether impaired glomerular filtration function is associated with the cardiac adverse remodeling in menopausal Chinese women with type 2 diabetes mellitus (DM).
METHODS
A total of 1231 hospitalized menopausal Chinese women with type 2 DM were collected retrospectively. The cross-sectional data of echocardiography were compared among estimated glomerular filtration rate (eGFR) categorized groups.
RESULTS
In menopausal diabetic women, moderate to severe glomerular filtration dysfunction (eGFR <60 mL/min per 1.73m) was found to be associated with enlarged left-side atrioventricular chambers, increased ventricular wall thickness, decreased cardiac function and dilated right ventricle (All < 0.05).
CONCLUSION
Glomerular filtration dysfunction is associated with cardiac adverse structural remodeling and dysfunction in menopausal Chinese women with type 2 DM.
背景
既往研究表明，肾病与成年糖尿病患者的心脏结构改变和功能障碍有关。然而，在绝经后糖尿病女性中，关于肾小球滤过功能障碍与心脏不良重塑之间关联的信息仍然有限。因此，我们研究了肾小球滤过功能受损是否与绝经后 2 型糖尿病中国女性的心脏不良重塑有关。
方法
回顾性收集了 1231 例住院绝经后 2 型糖尿病中国女性患者的资料。比较了根据估算肾小球滤过率（eGFR）分类的各组的超声心动图的横断面数据。
结果
在绝经后糖尿病女性中，发现中重度肾小球滤过功能障碍（eGFR＜60mL/min/1.73m）与左房室腔增大、心室壁增厚、心功能降低和右心室扩张有关（均 P＜0.05）。
结论
肾小球滤过功能障碍与绝经后 2 型糖尿病中国女性的心脏不良结构重塑和功能障碍有关。
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