Schmidt P J, Leparc G F, Samia C T
Southwest Florida Blood Bank, Tampa 33601.
Transfusion. 1988 Jul-Aug;28(4):389-91. doi: 10.1046/j.1537-2995.1988.28488265275.x.
Testing for anti-HBc has been recommended for use as a paradoxical or surrogate marker of carriers of non-A, non-B hepatitis. Serial sampling on a pool of 35,600 donors was done and those donors found to be repeatedly reactive by EIA method were rested using RIA methodology. Of 1367 donors found to be repeatedly reactive by EIA method, only 984 were confirmed by RIA. Those found to be reactive by EIA only were allowed to donate blood again, with only three of them becoming positive by both EIA and RIA on subsequent donations. The majority of these donors (107 out of 151) reverted to EIA negative status. Therefore, the finding of a positive anti-HBc by EIA method that could not be repeated by RIA method is not an early reproducible sign of anti-HBc reactive status.
抗-HBc检测已被推荐用作非甲非乙型肝炎携带者的矛盾或替代标志物。对35600名献血者的样本进行了连续抽样，那些通过酶免疫分析法（EIA）反复呈阳性反应的献血者，使用放射免疫分析法（RIA）进行复查。在1367名通过EIA法反复呈阳性反应的献血者中，只有984名经RIA法确认。那些仅通过EIA呈阳性反应的献血者被允许再次献血，其中只有3人在随后的献血中EIA和RIA均呈阳性。这些献血者中的大多数（151人中的107人）EIA转为阴性。因此，通过EIA法检测到的抗-HBc阳性结果若不能被RIA法重复，并非抗-HBc反应状态的早期可重复迹象。
