Programa de Pos-Graduacao em Ciencias da Reabilitacao, Universidade Nove de Julho (UNINOVE), Sao Paulo, SP, BR.
Departamento de Ciencias do Movimento, Universidade Federal de Sao Paulo (UNIFESP), Santos, SP, BR.
Clinics (Sao Paulo). 2021 Apr 16;76:e2474. doi: 10.6061/clinics/2021/e2474. eCollection 2021.
To compare the inflammatory and oxidative stress (OS) states of adults with bronchiectasis with those of healthy controls and correlate inflammatory and OS levels with lung function and physical capacity.
This study used a cross-sectional design. Seventy-four adults with bronchiectasis (age: 49±15 years, forced expiratory volume in 1 second [FEV1]: 52.5±25.6%) and 42 healthy controls (age: 44±17 years, FEV1: 95.9±14.0%) performed cardiopulmonary exercise tests and incremental shuttle walking tests. Their physical activity in daily life, inflammatory cytokine, and antioxidant levels in plasma were measured.
Compared to that of the controls, the levels of interleukin (IL)-6 (p<0.001), IL-10 (p<0.001), carbonylated proteins (p=0.001), and superoxide anions (p=0.046) were significantly increased in adults with bronchiectasis. Catalase activity was also reduced in this group (p<0.001). The inflammatory markers IL-1β, IL-6, and tumor necrosis factor-α correlated negatively with aerobic capacity (r=-0.408, r=-0.308, and r=-0.207, respectively). We observed similar correlations with OS markers (thiobarbituric acid and carbonyls; r=-0.290 and r=0.379, respectively), and these markers also significantly correlated with the aerobic capacity.
Adults with bronchiectasis presented an increased systemic inflammatory response that correlated negatively with physical capacity.
比较支气管扩张症患者与健康对照者的炎症和氧化应激（OS）状态，并将炎症和 OS 水平与肺功能和体力相关联。
本研究采用横断面设计。74 名支气管扩张症患者（年龄：49±15 岁，第 1 秒用力呼气量 [FEV1]：52.5±25.6%）和 42 名健康对照者（年龄：44±17 岁，FEV1：95.9±14.0%）进行心肺运动试验和递增式穿梭步行试验。测量其日常生活中的体力活动、血浆中的炎症细胞因子和抗氧化剂水平。
与对照组相比，支气管扩张症患者的白细胞介素（IL）-6（p<0.001）、IL-10（p<0.001）、羰基化蛋白（p=0.001）和超氧阴离子（p=0.046）水平显著升高。该组的过氧化氢酶活性也降低（p<0.001）。炎症标志物 IL-1β、IL-6 和肿瘤坏死因子-α 与有氧能力呈负相关（r=-0.408、r=-0.308 和 r=-0.207）。我们观察到与 OS 标志物（硫代巴比妥酸和羰基）也存在相似的相关性（r=-0.290 和 r=0.379），这些标志物也与有氧能力显著相关。
支气管扩张症患者表现出全身性炎症反应增加，与体力呈负相关。
