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癌症患者急性放射性皮炎:发生率和严重程度评估。

Acute radiodermatitis in cancer patients: incidence and severity estimates.

机构信息

Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Enfermagem, Brasília, DF, Brazil.

University of Washington, School of Medicine, Department of Rehabilitation Medicine, Seattle, WA, USA.

出版信息

Rev Esc Enferm USP. 2021 Apr 16;55:e03676. doi: 10.1590/S1980-220X2019021703676. eCollection 2021.

Abstract

OBJECTIVE

To estimate the incidence and distribution of the degree of radiodermatitis in cancer patients submitted to radiotherapy in the regions of head and neck, breast, and pelvis.

METHOD

Prospective, longitudinal, quantitative study conducted from March 15, 2016 to May 4, 2017 with patients observed for five weeks of treatment. The primary outcome was the proportion of grade 1 or higher radiodermatitis each week. The degree of radiodermatitis and mean time of occurrence for each patient were secondary outcomes.

RESULTS

This study included 112 patients. The incidence of radiodermatitis was 100% among those whose head and neck region was irradiated, followed by 98% for breast and 48% for the pelvic region. The degree of radiodermatitis varied with the irradiated site; the worst degrees were found in the head and neck region, followed by the breast. In the three groups, the mean time of the first occurrence of radiodermatitis was approximately eleven days.

CONCLUSION

The incidence of radiodermatitis in the studied groups was high, which reinforces the need to perform the same evaluation nationwide. This would support creating and standardizing protocols and recommendations for a proper management of radiodermatitis, specially concerning its prevention.

摘要

目的

评估头颈部、乳房和骨盆接受放疗的癌症患者放射性皮炎的发生率和程度分布。

方法

这是一项于 2016 年 3 月 15 日至 2017 年 5 月 4 日进行的前瞻性、纵向、定量研究,对患者进行了 5 周的治疗观察。主要结局是每周 1 级或更高放射性皮炎的比例。放射性皮炎的程度和每位患者的平均发生时间是次要结局。

结果

本研究共纳入 112 例患者。接受头颈部放疗的患者放射性皮炎发生率为 100%,其次是乳房 98%,骨盆 48%。放射性皮炎的程度随照射部位而异;头颈部最严重,其次是乳房。三组中,放射性皮炎首次发生的平均时间约为 11 天。

结论

研究组的放射性皮炎发生率较高,这加强了在全国范围内进行相同评估的必要性。这将支持制定和标准化方案,并为放射性皮炎的妥善管理提出建议,特别是在其预防方面。

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