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评估沙特阿拉伯慢性病患者的药物依从性。

Evaluation of medication adherence among patients with chronic diseases in Saudi Arabia.

机构信息

Department of Pharmacy Practice, College of Clinical Pharmacy, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia.

出版信息

Int J Clin Pract. 2021 Jul;75(7):e14253. doi: 10.1111/ijcp.14253. Epub 2021 May 13.

Abstract

BACKGROUND

Medication adherence in chronic diseases patients is a worldwide concern. Not achieving the goal of treatments because of non-adherence will lead to more complications and eventually may lead to death. In Saudi Arabia, we have insufficient data for interpretation. Hence, this study aims to have a better perspective at the number of the non-adherent patients with chronic diseases to their medications and its associated factors.

MATERIAL AND METHOD

Cross-sectional quantitative study was conducted among chronic diseases patients living in Saudi Arabia throughout social media and hospital visits from August 2018 to April 2019. A three-section questionnaire consists of patient's health, medications and adherence characteristics. Adherence to Refills and Medication Scale (ARMS) was used to identify the level of adherence among chronic diseases patients. Univariate descriptive statistics and independent sample t-test with one-way ANOVA were used as bivariate analysis. Finally, significant predictors of medical adherence with adjusted coefficient were determined by multivariable linear regression.

RESULTS

A total of 385 patients were included in the analysis for the current study. Overall, 96.62% (n = 372) were non-adherent to their medications according to ARMS scale. Multiple linear regression model found types of co-morbidities, medication dosage form and dosage regimen to be independent predictors of medical adherence.

CONCLUSION

Medication adherence is alarmingly low among chronic disease patients in Saudi Arabia. There is a clear need for in-depth understanding for barriers. It is therefore important to conduct a qualitative study. What's known Medication adherence is a critical factor in treatment success. Low adherence to the medication is a common problem among chronic disease patients. Moreover, the majority of the studies in Saudi Arabia showed low adherence rate, and it focused in one single chronic disease only despite that patient may have more. What's new Most patients had more than one single chronic disease, so this study aims to take a snapshot to capture the adherence rate among patients who are suffering from chronic disease Saudi Arabia and its associated factors. This can help in understanding medication adherence behavior in clinical practice.

摘要

背景

慢性病患者的用药依从性是一个全球性的问题。由于不依从治疗,无法达到治疗目标,将会导致更多的并发症,最终可能导致死亡。在沙特阿拉伯,我们缺乏相关数据来进行解读。因此,本研究旨在更好地了解慢性病患者不依从药物治疗的人数及其相关因素。

材料与方法

这是一项横断面定量研究,于 2018 年 8 月至 2019 年 4 月期间,通过社交媒体和医院就诊,在沙特阿拉伯的慢性病患者中进行。问卷由患者健康、用药和依从性特征三部分组成。采用 Refills and Medication Scale(ARMS)评估慢性病患者的依从性水平。采用单变量描述性统计和独立样本 t 检验及单因素方差分析进行二变量分析。最后,采用多元线性回归确定医疗依从性的显著预测因素,并计算调整后的系数。

结果

共有 385 名患者纳入本研究。根据 ARMS 量表,总体上有 96.62%(n=372)的患者不依从药物治疗。多变量线性回归模型发现,合并症类型、药物剂型和给药方案是医疗依从性的独立预测因素。

结论

沙特阿拉伯慢性病患者的用药依从性低得惊人。显然需要深入了解障碍因素。因此,进行定性研究很重要。已知信息:用药依从性是治疗成功的关键因素。慢性病患者普遍存在低用药依从性问题。此外,沙特阿拉伯的大多数研究显示出较低的依从率,且仅关注一种单一的慢性病,尽管患者可能患有多种疾病。新信息:大多数患者患有一种以上的慢性病,因此本研究旨在拍摄一张快照,以了解沙特阿拉伯慢性病患者的依从率及其相关因素。这有助于了解临床实践中的用药依从行为。

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