Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore.
Department for Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
BMJ Open Diabetes Res Care. 2021 Apr;9(1). doi: 10.1136/bmjdrc-2020-001396.
To determine if variations in the neonatal amygdala mediate the association between maternal antenatal glycemia and offspring adiposity in early childhood.
123 non-obese pregnant women with no pregnancy complications aside from gestational diabetes underwent a 75 g 2-hour oral glucose tolerance test at 26-28 weeks' gestation. Volume and fractional anisotropy (FA) of the neonatal amygdala (5-17 days old) were measured by MRI. The Body Mass Index (BMI) z-scores and sum of skinfold thickness (subscapular and triceps) of these children were tracked up to 60 months of age (18, 24, 36, 48, 54 and 60 months).
Maternal fasting glucose levels were positively associated with the offspring's sum of skinfold thickness at age 48 months (β=3.12, 95% CI 0.18 to 6.06 mm) and 60 months (β=4.14, 95% CI 0.46 to 7.82 mm) and BMI z-scores at 48 months (β=0.94, 95% CI 0.03 to 1.85), 54 months (β=0.74, 95% CI 0.12 to 1.36) and 60 months (β=0.74, 95% CI 0.08 to 1.39). Maternal fasting glucose was negatively associated with the offspring's FA of the right amygdala (β=-0.019, 95% CI -0.036 to -0.003). Right amygdala FA was negatively associated with the sum of skinfold thickness in the offspring at age 48 months (β=-56.95, 95% CI -98.43 to -15.47 mm), 54 months (β=-46.18, 95% CI -88.57 to -3.78 mm), and 60 months (β=-53.69, 95% CI -105.74 to -1.64 mm). The effect sizes mediated by right amygdala FA between fasting glucose and sum of skinfolds were estimated at β=5.14 (95% CI 0.74 to 9.53) mm (p=0.022), β=4.40 (95% CI 0.08 to 8.72) (p=0.049) mm and β=4.56 (95% CI -0.17 to 9.29) mm (p=0.059) at 48, 54 and 60 months, respectively.
In the offspring of non-obese mothers, gestational fasting glucose concentration is negatively associated with neonatal right amygdala FA and positively associated with childhood adiposity. Neonatal right amygdala FA may be a potential mediator between maternal glycemia and childhood adiposity.
为了确定新生儿杏仁核的变化是否介导了母体产前血糖与儿童早期肥胖之间的关系。
123 名非肥胖孕妇，除妊娠期糖尿病外，无其他妊娠并发症，在 26-28 周妊娠时进行 75g 2 小时口服葡萄糖耐量试验。通过 MRI 测量新生儿杏仁核（5-17 天）的体积和各向异性分数（FA）。这些儿童的 BMI 得分和皮褶厚度总和（肩胛下和肱三头肌）在 60 个月时（18、24、36、48、54 和 60 个月）进行跟踪。
母亲空腹血糖水平与儿童 48 个月时的皮褶厚度总和（β=3.12，95%CI 0.18 至 6.06mm）和 60 个月时的 BMI 得分（β=0.94，95%CI 0.03 至 1.85）、54 个月时的 BMI 得分（β=0.74，95%CI 0.12 至 1.36）和 60 个月时的 BMI 得分（β=0.74，95%CI 0.08 至 1.39）呈正相关。母亲空腹血糖与儿童右杏仁核的 FA 呈负相关（β=-0.019，95%CI-0.036 至-0.003）。右杏仁核 FA 与儿童 48 个月时的皮褶厚度总和呈负相关（β=-56.95，95%CI-98.43 至-15.47mm）、54 个月时的皮褶厚度总和（β=-46.18，95%CI-88.57 至-3.78mm）和 60 个月时的皮褶厚度总和（β=-53.69，95%CI-105.74 至-1.64mm）。右杏仁核 FA 介导的空腹血糖与皮褶厚度总和之间的效应大小估计为β=5.14（95%CI 0.74 至 9.53）mm（p=0.022）、β=4.40（95%CI 0.08 至 8.72）mm（p=0.049）mm 和β=4.56（95%CI-0.17 至 9.29）mm（p=0.059），分别在 48、54 和 60 个月时。
在非肥胖母亲的后代中，妊娠期空腹血糖浓度与新生儿右杏仁核 FA 呈负相关，与儿童肥胖呈正相关。新生儿右杏仁核 FA 可能是母体血糖与儿童肥胖之间的潜在中介。
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