• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于鉴定针对[疾病名称1]和[疾病名称2]的常见治疗方法的反向疫苗学和消减基因组学方法。

Reverse vaccinology and subtractive genomics approaches for identifying common therapeutics against and .

作者信息

Jaiswal Arun Kumar, Tiwari Sandeep, Jamal Syed Babar, Oliveira Letícia de Castro, Sales-Campos Helioswilton, Andrade-Silva Leonardo Eurípedes, Oliveira Carlo Jose Freire, Ghosh Preetam, Barh Debmalya, Azevedo Vasco, Soares Siomar C, Rodrigues Virmondes Rodrigues, da Silva Marcos Vinicius

机构信息

Graduate Program in Bioinformatics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Department of Immunology, Microbiology and Parasitology, Institute of Biological Sciences and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.

出版信息

J Venom Anim Toxins Incl Trop Dis. 2021 Apr 9;27:e20200027. doi: 10.1590/1678-9199-JVATITD-2020-0027.

DOI:10.1590/1678-9199-JVATITD-2020-0027
PMID:33889182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8040911/
Abstract

BACKGROUND

and are gram-positive bacterial pathogens and the causative agents of leprosy in humans across the world. The elimination of leprosy cannot be achieved by multidrug therapy alone, and highlights the need for new tools and drugs to prevent the emergence of new resistant strains.

METHODS

In this study, our contribution includes the prediction of vaccine targets and new putative drugs against leprosy, using reverse vaccinology and subtractive genomics. Six strains of and (4 and 2 strains, respectively) were used for comparison taking strain TN as the reference genome. Briefly, we used a combined reverse vaccinology and subtractive genomics approach.

RESULTS

As a result, we identified 12 common putative antigenic proteins as vaccine targets and three common drug targets against and Furthermore the docking analysis using 28 natural compounds with three drug targets was done.

CONCLUSIONS

The bis-naphthoquinone compound Diospyrin (CID 308140) obtained from indigenous plant spp showed the most favored binding affinity against predicted drug targets, which can be a candidate therapeutic target in the future against leprosy.

摘要

背景

[菌名1]和[菌名2]是革兰氏阳性细菌病原体，也是全球人类麻风病的病原体。仅通过多药疗法无法实现消除麻风病的目标，这凸显了需要新的工具和药物来防止新的耐药菌株出现。

方法

在本研究中，我们的贡献包括使用反向疫苗学和消减基因组学预测麻风病的疫苗靶点和新的潜在药物。以[菌名1]菌株TN作为参考基因组，使用6株[菌名1]和[菌名2]（分别为4株和2株）进行比较。简而言之，我们采用了反向疫苗学和消减基因组学相结合的方法。

结果

结果，我们鉴定出12种常见的潜在抗原蛋白作为疫苗靶点，以及3种针对[菌名1]和[菌名2]的常见药物靶点。此外，还使用28种天然化合物对3个药物靶点进行了对接分析。

结论

从本土植物[植物名]中获得的双萘醌化合物柿素（CID 308140）对预测的药物靶点显示出最有利的结合亲和力，未来可能成为治疗麻风病的候选治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/7769e11c08a0/1678-9199-jvatitd-27-e20200027-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/fcdec21a8dbe/1678-9199-jvatitd-27-e20200027-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/ebf23896108b/1678-9199-jvatitd-27-e20200027-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/f5098f484509/1678-9199-jvatitd-27-e20200027-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/d861a6d49b1a/1678-9199-jvatitd-27-e20200027-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/2900195dfe23/1678-9199-jvatitd-27-e20200027-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/7769e11c08a0/1678-9199-jvatitd-27-e20200027-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/fcdec21a8dbe/1678-9199-jvatitd-27-e20200027-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/ebf23896108b/1678-9199-jvatitd-27-e20200027-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/f5098f484509/1678-9199-jvatitd-27-e20200027-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/d861a6d49b1a/1678-9199-jvatitd-27-e20200027-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/2900195dfe23/1678-9199-jvatitd-27-e20200027-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79f8/8040911/7769e11c08a0/1678-9199-jvatitd-27-e20200027-gf6.jpg

相似文献

1
Reverse vaccinology and subtractive genomics approaches for identifying common therapeutics against and .用于鉴定针对[疾病名称1]和[疾病名称2]的常见治疗方法的反向疫苗学和消减基因组学方法。
J Venom Anim Toxins Incl Trop Dis. 2021 Apr 9;27:e20200027. doi: 10.1590/1678-9199-JVATITD-2020-0027.
2
Mycobacterium leprae and Mycobacterium lepromatosis Infection: a Report of Six Multibacillary Cases of Leprosy in the Dominican Republic.麻风分枝杆菌和麻风分枝杆菌感染：多米尼加共和国 6 例多菌型麻风病例报告。
Jpn J Infect Dis. 2022 Jul 22;75(4):427-430. doi: 10.7883/yoken.JJID.2021.709. Epub 2022 Mar 31.
3
Construction and Analysis of the Complete Genome Sequence of Leprosy Agent Mycobacterium lepromatosis.构建并分析麻风分枝杆菌全基因组序列。
Microbiol Spectr. 2022 Jun 29;10(3):e0169221. doi: 10.1128/spectrum.01692-21. Epub 2022 Apr 25.
4
Insight into the evolution and origin of leprosy bacilli from the genome sequence of Mycobacterium lepromatosis.从麻风分枝杆菌的基因组序列洞察麻风杆菌的进化与起源。
Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4459-64. doi: 10.1073/pnas.1421504112. Epub 2015 Mar 23.
5
Isolation of Mycobacterium lepromatosis and Development of Molecular Diagnostic Assays to Distinguish Mycobacterium leprae and M. lepromatosis.麻风分枝杆菌的分离及其分子诊断检测方法的建立，以区分麻风分枝杆菌和麻风分枝杆菌。
Clin Infect Dis. 2020 Nov 5;71(8):e262-e269. doi: 10.1093/cid/ciz1121.
6
Analysis of the leprosy agents Mycobacterium leprae and Mycobacterium lepromatosis in four countries.四国麻风分枝杆菌和麻风分枝杆菌潜伏亚种的分析。
Am J Clin Pathol. 2014 Oct;142(4):524-32. doi: 10.1309/AJCP1GLCBE5CDZRM.
7
Comparative sequence analysis of Mycobacterium leprae and the new leprosy-causing Mycobacterium lepromatosis.麻风分枝杆菌与新发现的致麻风病的利氏麻风分枝杆菌的比较序列分析。
J Bacteriol. 2009 Oct;191(19):6067-74. doi: 10.1128/JB.00762-09. Epub 2009 Jul 24.
8
Leprosy Caused by Mycobacterium lepromatosis.由瘤型麻风分枝杆菌引起的麻风病。
Am J Clin Pathol. 2022 Dec 1;158(6):678-686. doi: 10.1093/ajcp/aqac110.
9
Identification of and in Formalin-Fixed and Paraffin-Embedded Skin Samples from Mexico.墨西哥福尔马林固定石蜡包埋皮肤样本中[具体物质]的鉴定。 （原文中“and”前后内容缺失，翻译时按照完整句子结构补充了“[具体物质]”）
Ann Dermatol. 2018 Oct;30(5):562-565. doi: 10.5021/ad.2018.30.5.562. Epub 2018 Aug 28.
10
Identification of Putative Vaccine and Drug Targets against the Methicillin-Resistant by Reverse Vaccinology and Subtractive Genomics Approaches.通过反向疫苗学和消减基因组学方法鉴定耐甲氧西林的潜在疫苗和药物靶标。
Molecules. 2022 Mar 24;27(7):2083. doi: 10.3390/molecules27072083.

引用本文的文献

1
Integrated Bioinformatics-Based Subtractive Genomics Approach to Decipher the Therapeutic Drug Target and Its Possible Intervention against Brucellosis.基于综合生物信息学的消减基因组学方法来破译治疗药物靶点及其对布鲁氏菌病的可能干预措施。
Bioengineering (Basel). 2022 Nov 1;9(11):633. doi: 10.3390/bioengineering9110633.
2
In silico designing of a recombinant multi-epitope antigen for leprosy diagnosis.用于麻风病诊断的重组多表位抗原的计算机辅助设计
J Genet Eng Biotechnol. 2022 Sep 2;20(1):128. doi: 10.1186/s43141-022-00411-7.
3
A review of nutrition in neuropathic pain of leprosy.

本文引用的文献

1
Evidence for Drug Resistance in a Large Cohort of Leprous Neuropathy Patients from India.印度大量麻风神经病变患者的耐药证据。
Am J Trop Med Hyg. 2020 Mar;102(3):547-552. doi: 10.4269/ajtmh.19-0390.
2
Molecular surveillance of antimicrobial resistance and transmission pattern of in Chinese leprosy patients.中国麻风病患者中抗菌药物耐药性和传播模式的分子监测。
Emerg Microbes Infect. 2019;8(1):1479-1489. doi: 10.1080/22221751.2019.1677177.
3
Reverse vaccinology and subtractive genomics reveal new therapeutic targets against : a causative agent of pneumonia.
麻风病神经性疼痛的营养状况综述。
Ther Adv Infect Dis. 2022 Jun 1;9:20499361221102663. doi: 10.1177/20499361221102663. eCollection 2022 Jan-Dec.
反向疫苗学和消减基因组学揭示了针对肺炎病原体的新治疗靶点。
R Soc Open Sci. 2019 Jul 31;6(7):190907. doi: 10.1098/rsos.190907. eCollection 2019 Jul.
4
The Continuing Relevance of Leprosy.麻风病的持续相关性
JAMA Dermatol. 2019 Oct 1;155(10):1107-1108. doi: 10.1001/jamadermatol.2019.1730.
5
Microbial genomic island discovery, visualization and analysis.微生物基因组岛的发现、可视化和分析。
Brief Bioinform. 2019 Sep 27;20(5):1685-1698. doi: 10.1093/bib/bby042.
6
Putative vaccine candidates and drug targets identified by reverse vaccinology and subtractive genomics approaches to control , the causative agent of chancroid.通过反向疫苗学和消减基因组学方法识别的控制软性下疳病原体的候选疫苗和药物靶点。
J R Soc Interface. 2018 May;15(142). doi: 10.1098/rsif.2018.0032.
7
Leprosy and gender in Brazil: trends in an endemic area of the Northeast region, 2001-2014.巴西的麻风病与性别问题：2001 - 2014年东北地区流行区的趋势
Rev Saude Publica. 2018;52:20. doi: 10.11606/s1518-8787.2018052000335. Epub 2018 Feb 26.
8
The Druggable Pocketome of : A New Approach for Putative Druggable Targets.[具体研究对象]的可药物化口袋组学：一种寻找潜在可药物靶点的新方法 。（需注意原文中“:”前缺失具体研究对象相关内容）
Front Genet. 2018 Feb 13;9:44. doi: 10.3389/fgene.2018.00044. eCollection 2018.
9
Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview.作为抗菌治疗靶点的病原菌双组分信号转导系统：综述
Front Microbiol. 2017 Oct 10;8:1878. doi: 10.3389/fmicb.2017.01878. eCollection 2017.
10
An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae.一种用于鉴定人类病原体白喉棒状杆菌治疗靶点的整合计算机方法。
PLoS One. 2017 Oct 19;12(10):e0186401. doi: 10.1371/journal.pone.0186401. eCollection 2017.