Department of Internal Medicine, Nnamdi Azikiwe University, Anambra State, Nigeria.
Department of Community Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Pan Afr Med J. 2021 Jan 20;38:66. doi: 10.11604/pamj.2021.38.66.21707. eCollection 2021.
tuberculosis (TB) remains a global health issue with high morbidity and mortality rates especially in the developing countries. It is a multi-organ disease and can influence biochemical changes. This study sought to determine the influence of tuberculosis and its drug treatment on serum biochemical parameters in patients in Nigeria.
it was a descriptive observational cohort study on 150 subjects whose blood samples were analyzed for serum albumin, serum sodium, and serum potassium. The subjects were grouped into 3: TB group= 50 new TB subjects not on treatment, F group= 50 TB subjects on treatment for 2/12 or more and C group= 50 non-TB control subjects. These biochemical variables were compared between the 3 groups.
male/female ratio was 1: 1.5, mean age 37.1±0.92 years, and range 18-65 years. The differences in mean values of serum albumin, calcium and sodium between the three groups were significant (p<0.001), whereas that of serum potassium was not significant (p=0.056). Those patients with new case TB had a significantly lower serum sodium, serum albumin and serum calcium than the control group and those on treatment, p<0.001. There was significant positive correlation between serum albumin and serum calcium (r=0.0.420, p<0.001) as well as serum sodium (r=0.310, p<0.001) in the study population. Similarly, the correlation between serum calcium and serum sodium was positive and significant (r=0.200, p=0.014). In contrast, the correlation between serum potassium and serum albumin and that between serum potassium and serum calcium was not significant.
tuberculosis with or without anti-tuberculous medications was associated with significant reduction in serum albumin, serum sodium and serum calcium in this study.
结核病（TB）仍然是一个全球性的健康问题，发病率和死亡率都很高，尤其是在发展中国家。它是一种多器官疾病，可以影响生化变化。本研究旨在确定结核病及其药物治疗对尼日利亚患者血清生化参数的影响。
这是一项关于 150 名受试者的描述性观察队列研究，对他们的血液样本进行血清白蛋白、血清钠和血清钾分析。受试者分为 3 组：TB 组=50 名未接受治疗的新结核病患者，F 组=50 名接受治疗 2/12 个月或更长时间的结核病患者，C 组=50 名非结核病对照受试者。比较了这 3 组之间的这些生化变量。
男女比例为 1:1.5，平均年龄为 37.1±0.92 岁，年龄范围为 18-65 岁。三组间血清白蛋白、钙和钠的均值差异有统计学意义（p<0.001），而血清钾的均值差异无统计学意义（p=0.056）。新诊断结核病患者的血清钠、血清白蛋白和血清钙均显著低于对照组和治疗组，p<0.001。研究人群中血清白蛋白与血清钙（r=0.0.420，p<0.001）和血清钠（r=0.310，p<0.001）呈显著正相关。同样，血清钙与血清钠之间的相关性也是正相关且显著的（r=0.200，p=0.014）。相反，血清钾与血清白蛋白和血清钙之间的相关性无统计学意义。
本研究表明，结核病（无论是否接受抗结核药物治疗）均与血清白蛋白、血清钠和血清钙显著降低有关。
