Ramakrishnan Kuppamuthu, Shenbagarathai Rajaiah, Kavitha Karuppusamy, Uma Alagappa, Balasubramaniam Ramakrishnan, Thirumalaikolundusubramanian Ponniah
Tuberculosis Research Centre, Madurai, India.
Jpn J Infect Dis. 2008 May;61(3):202-4.
Limited data are available on the relationship between nutritional status and pulmonary tuberculosis (PTB). Zinc plays a vital role in the immune status of the individual. The present study was carried out to estimate serum zinc and albumin levels in newly detected adult active PTB patients with (n = 20) and without (n = 20) HIV, and to compare them with the levels in controls (healthy family members; n = 20) who satisfied rigid selection criteria. Standard methods were adopted to collect an early morning fasting blood sample for zinc (by Atomic Absorption Spectrometer) and albumin (estimated by the bromocresol green method). The mean +/- SD for BMI, zinc and albumin among the controls, HIV positive and HIV negative patients were 19.6 +/- 0.6, 18 +/- 0.4 and 18.5 +/- 0.6 kg/m(2); 117.13 +/- 4.2, 53.9 +/- 8 and 65.5 +/- 9.8 microg/dL; and 4.1 +/- 0.6, 2.9 +/- 0.4 and 3.6 +/- 0.7 g/dL, respectively. All three parameters were significantly low in active PTB patients irrespective of HIV status, but more so in HIV-positive individuals. These changes may be attributable to nutritional factors, enteropathy and acute phase reactant proteins. Hence, the National AIDS Control Organization (NACO) in India is providing nutritional supplements to those HIV-infected cases inducted for antiretroviral therapy and nutritional counseling for others as a part of a national policy.
关于营养状况与肺结核（PTB）之间的关系，现有数据有限。锌在个体免疫状态中起着至关重要的作用。本研究旨在评估新检测出的成年活动性肺结核患者（n = 20）合并或未合并（n = 20）HIV时的血清锌和白蛋白水平，并将其与符合严格选择标准的对照组（健康家庭成员；n = 20）的水平进行比较。采用标准方法采集清晨空腹血样，用于检测锌（通过原子吸收光谱仪）和白蛋白（采用溴甲酚绿法测定）。对照组、HIV阳性患者和HIV阴性患者的BMI、锌和白蛋白的均值±标准差分别为19.6±0.6、18±0.4和18.5±0.6kg/m²；117.13±4.2、53.9±8和65.5±9.8μg/dL；以及4.1±0.6、2.9±0.4和3.6±0.7g/dL。无论HIV状态如何，活动性肺结核患者的这三个参数均显著降低，但HIV阳性个体更为明显。这些变化可能归因于营养因素、肠病和急性期反应蛋白。因此，印度国家艾滋病控制组织（NACO）作为一项国家政策的一部分，正在为接受抗逆转录病毒治疗的HIV感染病例提供营养补充剂，并为其他患者提供营养咨询。
