Wang Qingchun, Siok Wai Ting
Department of Linguistics, The University of Hong Kong, Hong Kong, China.
Beilstein J Nanotechnol. 2021 Apr 8;12:330-342. doi: 10.3762/bjnano.12.27. eCollection 2021.
In recent years, researchers have studied how nanotechnology could enhance neuroimaging techniques. The application of nanomaterial-based flexible electronics has the potential to advance conventional intracranial electroencephalography (iEEG) by utilising brain-compatible soft nanomaterials. The resultant technique has significantly high spatial and temporal resolution, both of which enhance the localisation of brain functions and the mapping of dynamic language processing. This review presents findings on aphasia, an impairment in language and communication, and discusses how different brain imaging techniques, including positron emission tomography, magnetic resonance imaging, and iEEG, have advanced our understanding of the neural networks underlying language and reading processing. We then outline the strengths and weaknesses of iEEG in studying human cognition and the development of intracranial recordings that use brain-compatible flexible electrodes. We close by discussing the potential advantages and challenges of future investigations adopting nanomaterial-based flexible electronics for intracranial recording in patients with aphasia.
近年来，研究人员一直在研究纳米技术如何能够增强神经成像技术。基于纳米材料的柔性电子器件的应用有潜力通过利用与大脑兼容的软纳米材料来推进传统的颅内脑电图（iEEG）技术。由此产生的技术具有显著高的空间和时间分辨率，这两者都增强了脑功能的定位以及动态语言处理的映射。本综述介绍了关于失语症（一种语言和交流障碍）的研究结果，并讨论了不同的脑成像技术，包括正电子发射断层扫描、磁共振成像和iEEG，如何推进了我们对语言和阅读处理背后神经网络的理解。然后，我们概述了iEEG在研究人类认知方面的优缺点以及使用与大脑兼容的柔性电极的颅内记录技术的发展情况。最后，我们讨论了未来采用基于纳米材料的柔性电子器件对失语症患者进行颅内记录的研究可能具有的优势和挑战。
