Mo Fan-E
Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Front Cell Dev Biol. 2021 Apr 6;9:640781. doi: 10.3389/fcell.2021.640781. eCollection 2021.
Mechanical forces imposed by blood flow shear stress directly modulate endothelial gene expression and functional phenotype. The production of extracellular matrix proteins and corresponding cell-surface integrin receptors in arterial endothelial cells is intricately regulated by blood flow patterns. Laminar blood flow promotes mature and atheroresistant endothelial phenotype, while disturbed flow induces dysfunctional and atheroprone endothelial responses. Here, we discuss how hemodynamic changes orchestrate the remodeling of extracellular microenvironments and the expression profile of the integrin receptors in endothelial cells leading to oxidative stress and inflammation. Targeting the interaction between matrix proteins and their corresponding integrins is a potential therapeutic approach for atherosclerosis.
血流剪切应力施加的机械力直接调节内皮基因表达和功能表型。动脉内皮细胞中细胞外基质蛋白和相应细胞表面整合素受体的产生受到血流模式的复杂调控。层流促进成熟且抗动脉粥样硬化的内皮表型，而紊乱血流则诱导功能失调且易致动脉粥样硬化的内皮反应。在此，我们讨论血流动力学变化如何协调细胞外微环境的重塑以及内皮细胞中整合素受体的表达谱，从而导致氧化应激和炎症。针对基质蛋白与其相应整合素之间的相互作用是一种潜在的动脉粥样硬化治疗方法。
