Zhejiang Provincial Center for Disease Control and Prevention, No. 3399 Binsheng Road, Binjiang District, Hangzhou, 310051, Zhejiang, China.
National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, No.7 Panjiayuannanli, Chaoyang District, Beijing, 100021, China.
Environ Sci Pollut Res Int. 2021 Sep;28(34):47367-47374. doi: 10.1007/s11356-021-14043-w. Epub 2021 Apr 23.
Previous studies have proved that particulate air pollution was related to adverse cardiovascular effects. However, most studies focused on the acute effects of short-term fine particulate matter (PM) exposure and the general population. Evidence from long-term cohort studies based on the cardiovascular disease (CVD) patients was scarce. Our study aimed to explore the impact of long-term exposure to PM on the mortality among post-CVD patients. This is a cohort study that involved 5143 post-CVD patients in Beijing, China. We collected records of CVD patients from hospitals in Beijing, China from 1 January 2012 to 31 December 2012 and followed up these patients from hospital admission until December 31, 2016. The vital status of the patients was determined using the National Death Surveillance Point System (DSPs). The PM concentrations were obtained from the Atmospheric Composition Analysis Group. The Cox regression models were used for data analyses. Our findings suggested that increased mortality of CVD patients with an HR of 1.43 (95% CI: 1.24, 1.63) was related to long-term exposure to PM. The association was stronger for cardiovascular-related mortality, especially for mortality from myocardial infarction (MI). The HR for any CVD mortality was 1.57 (95% CI: 1.27, 1.94), HR for MI mortality was 1.82 (95% CI: 1.16, 2.83). Long-term PM exposure may significantly affect the survival of CVD patients. Compared with the general population, patients with CVD are more susceptible to PM exposure. Increased attention to the management of CVD patients is warranted.
先前的研究已经证明，颗粒物空气污染与不良心血管效应有关。然而，大多数研究都集中在短期细颗粒物（PM）暴露的急性效应和一般人群上。基于心血管疾病（CVD）患者的长期队列研究证据很少。我们的研究旨在探讨长期暴露于 PM 对 CVD 后患者死亡率的影响。这是一项在中国北京进行的队列研究，涉及 5143 名 CVD 后患者。我们从中国北京的医院收集了 CVD 患者的记录，时间范围为 2012 年 1 月 1 日至 2012 年 12 月 31 日，并对这些患者进行了随访，从入院到 2016 年 12 月 31 日。患者的生存状态通过国家死亡监测点系统（DSPs）确定。PM 浓度从大气成分分析组获得。使用 Cox 回归模型进行数据分析。我们的研究结果表明，长期暴露于 PM 与 CVD 患者死亡率增加有关，风险比（HR）为 1.43（95%置信区间：1.24，1.63）。与心血管相关的死亡率关联更强，尤其是心肌梗死（MI）死亡率。任何 CVD 死亡率的 HR 为 1.57（95%置信区间：1.27，1.94），MI 死亡率的 HR 为 1.82（95%置信区间：1.16，2.83）。长期 PM 暴露可能显著影响 CVD 患者的生存。与一般人群相比，CVD 患者更容易受到 PM 暴露的影响。需要加强对 CVD 患者的管理。
